Naslov
Cerebral palsy in children with symptomatic congenital cytomegalovirus infection - clinical features and neuroimaging findings

Autori
Mejaški-Bošnjak, Vlatka ; Đaković, Ivana ; Đuranović, Vlasta ; Lujić, Lucija ; Delin, Sanja ; Tešović, Goran ; Grmoja, Tonći

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
European Congenital Cytomegalovirus Initiative, 24th - 26th April, 2016, Venice, Italy. Abstrakt book. / - , 2016, 105-105

Skup
European Congenital Cytomegalovirus Initiative, 24th - 26th April, 2016, Venice, Italy.

Mjesto i datum
Venecija, Italija, 24.04.2016. - 26.04.2016

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
cerebral palsy ; children ; symptomatic congenital cytomegalovirus infection ; clinical features ; neuroimaging

Sažetak
Background: Congenital cytomegalovirus infection (cCMV) is the most common infectious cause of neurodevelopmental disorders in childhood, including cerebral palsy (CP). In Australian CP register children with cCMV infection accounted for 1.5% of all CP cases with prevalence of 2.5/100 000 live births. Our aim is to present clinical features and neuroimaging findings in children with symptomatic cCMV infection. Study comprised 18 children with proven cCMV infection who were diagnosed as having CP. Classification of CP and associated impairments was performed according to proposal of Surveillance of Cerebral Palsy in Europe. At the time of diagnosis and classification children were aged between 4 and 16 years. Only one child was preterm, while 17 children were termborn. Neuroimaging study has been performed in all children, initially CT in older children, and later MRI in all. Results: 15/18 patients had bilateral spastic (BS) CP, two had dyskinetic and one child ataxic CP. Five children with BS CP had good walking abilities and six were wheel chair dependent. In all patients BS CP was accompanied by moderate to severe mental retardation (MR), in 9 by epilepsy, in 7 by sensorineuronal deafness (SND), in another 7 by chorioretinitis and by autistic spectrum disorder (ASD) in one. Dyskinetic CP was in both patients of most severe grade, GMFCS V, accompanied by severe MR, SND, chorioretinitis and ASD. The only child with ataxic CP, had GMFCS I, but had severe mental retardation. Microcephaly was present in 15/18 children. Brain malformations were the predominant imaging pattern in 11/18 of children with cCMV and CP, the most common polimicrogyria and pachygyria, in four children each, lissencephaly in two and shizencephaly in one child. Migration disturbances were accompanied by cerebellar hypoplasia in four and leukoecephalopahy in four children. Isolated leukoencephalopathy was present in 6/18 cases, diffuse with bilateral temporal cysts in two. One child had marked brain atrophy and hypoplastic corpus callosum. Calcifications were present in 12/18 children. Conclusion: Cerebral palsy following symptomatic cCMV infection is in most cases a severe condition. Associated impairments are overrepresented and often severe (particularly hearing). It is more often in females and term born. Brain malformations are the most common neuroimaging pattern.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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