Pregled bibliografske jedinice broj: 838491
Nano- and Microparticles in Oral Delivery of Macromolecular Drugs
Nano- and Microparticles in Oral Delivery of Macromolecular Drugs // Oral Delivery of Macromolecular Drugs / Bernkop-Schnürch, Andreas (ur.).
New York (NY): Springer, 2009. str. 153-167
CROSBI ID: 838491 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Nano- and Microparticles in Oral Delivery of Macromolecular Drugs
Autori
Millotti, Gioconda ; Bernkop-Schnuerch, Andreas
Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, znanstveni
Knjiga
Oral Delivery of Macromolecular Drugs
Urednik/ci
Bernkop-Schnürch, Andreas
Izdavač
Springer
Grad
New York (NY)
Godina
2009
Raspon stranica
153-167
ISBN
978-1-4419-0199-6
Ključne riječi
nanoparticles, microparticles, oral delivery, macromolecular drugs
(cles, microparticles, oral delivery, macromolecular drugs)
Sažetak
Oral delivery systems are highly demanded and preferred over parenteral systems as they offer an ease of administration and therefore a high patient compliance. A promising strategy in order to improve the oral uptake of macromolecular drugs is the use of micro- and nanoparticulate delivery systems. The most widely used materials and techniques applied in the development of micro- and nanocarrier systems are described as well as the strategies to modify the particle’s surface in order to modulate their characteristics such as mucoadhesion, stability, protective effect, hydrophilicity or lipophilicity. Particles’ properties such as membrane-passing properties, permeation-enhancing properties, mucoadhesive properties, and protective properties are extensively discussed. Furthermore, evidence for the potential of such systems is provided with examples from recent in vivo studies.
Izvorni jezik
Engleski
Znanstvena područja
Farmacija
