Pregled bibliografske jedinice broj: 836882
4α-Methylated steroids with cytotoxic activity from the soft coral Litophyton mollis
4α-Methylated steroids with cytotoxic activity from the soft coral Litophyton mollis // Steroids, 115 (2016), 130-135 doi:10.1016/j.steroids.2016.08.017 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 836882 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
4α-Methylated steroids with cytotoxic activity from the soft coral Litophyton mollis
Autori
Zovko Končić, Marijana ; Ioannou, Efstathia ; Sawadogo, Wamtinga Richard ; Abdel-Razik, Ayman F. ; Vagias, Constantinos ; Diederich, Marc ; Roussis, Vassilios
Izvornik
Steroids (0039-128X) 115
(2016);
130-135
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
4α-Methylated steroids ; Cytotoxic activity ; Litophyton mollis ; Structure elucidation
Sažetak
Seven new (1–3, 5 and 8–10) and three previously reported (4, 6 and 7) 4α-methylated steroids were isolated from the organic extract of the gorgonian Litophyton mollis. The structures and the relative configurations of the isolated natural products were determined on the basis of extensive analyses of their NMR and MS data. Metabolites 1 and 5–8 exhibited cytotoxic activity against K562 human chronic myelogenous leukemia cells with IC50 values below 10 μM, while at the same time displaying low toxicity against healthy PBMCs. © 2016 Elsevier Inc.
Izvorni jezik
Engleski
Znanstvena područja
Farmacija
POVEZANOST RADA
Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb
Profili:
Marijana Zovko Končić
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- Arts & Humanities Citation Index (A&HCI)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
