Naslov
CLINICAL SIGNIFICANCE OF DRUG METABOLITE PROFILING

Autori
Željko Debeljak

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
8th Croatian Congress of Pharmacology with International Participation: Final Programme and Abstract Book / Boban, Mladen - Split : Hrvatsko farmaceutsko društvo ; Sveučilište u Splitu, 2016, 32-32

Skup
8th Croatian Congress of Pharmacology with International Participation

Mjesto i datum
Split, Hrvatska, 15.09.2016. - 18.09.2016

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Therapeutic drug monitoring; metabolite profiling; clinical significance
(Praćenje terapije lijekovima; probir metabolita; klinički značaj)

Sažetak
General biotransformation mechanisms of xenobiotics in humans have been largely elucidated during the last three decades. Until recently, this accumulated knowledge of biotransformation mechanisms have not been significantly utilized in the clinical settings. Recently, these biotransformation pathways stepped outside of boundaries of academic importance, finding their utility in the therapeutic drug monitoring and forensic medicine. Metabolite profiling has also gained importance and utility as a tool used in pharmacovigilance and as a prognostic marker for the therapeutic outcomes. As is the case with the parent compounds, metabolite profiling is used for monitoring of drugs characterized by the narrow therapeutic range: quantitative determination of immunosuppressants, antiepileptics, psychoactive and anticancer drug metabolites has already entered the routine clinical application. A critical overview of the literature and case study evidence supporting the metabolite profiling applications in the clinical settings will be presented.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Kliničke medicinske znanosti, Farmacija

POVEZANOST RADA