Naslov
Replication-related constraints on the evolution of archaeal genome structure

Autori
Repar, Jelena ; Warnecke, Tobias

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Molecular Biology of Archaea 5 Poster Abstract Book / - , 2016

Skup
Molecular Biology of Archaea 5

Mjesto i datum
London, Ujedinjeno Kraljevstvo, 01.08.2016. - 03.08.2016

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
genome structure evolution; inversions; selection; prokaryotes

Sažetak
Prokaryotic genomes are generally organized in a way that enables fast DNA replication and cell division. This genome organization includes features such as positioning highly expressed genes close to the origin of replication and placing essential genes on the leading strand. To what extent these organizational principles constrain short- and long-term evolution of genome structure in archaea, however, remains largely unexplored. Here, we characterize the distribution of inversions and synteny breakpoints in various archaeal clades. We observe widespread nonrandom breakpoint and inversion patterns in both euryarchaea and crenarchaea, with a tendency towards inversions that are symmetric around the origin of replication. Our findings are consistent with ongoing selection for the conservation of local gene neighbourhoods around the origin of replication, and for maintenance of distance relationships around the origin of replication. Notably, we find similar patterns in genomes with single and multiple origins of replication such as Sulfolobus, where principles of genome organization and evolution apply to individual origin territories.

Izvorni jezik
Engleski

Znanstvena područja
Računarstvo

POVEZANOST RADA