Naslov
Thyroiditis and Vitamin D.

Autori
Miškić, Blaženka ; Zukanović, Sidbela ; Ćosić, Vesna ; Knežević Preveček, Marijana ; Jandrić Balen, Marica ; Miškić, Karla ; Moser, Nataša

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
European Thyroid Journal / - , 2016

Skup
39th Annual Meeting of the European Thyroid Association

Mjesto i datum
Kopenhagen, Danska, 03.-06.09

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Thyroiditis; Vitamin D

Sažetak
Introduction: A low level of vitamin D accelerates the lack of immune tolerance on thyroid cells. High level of interleukins and chemotaxic factors contributed to inflamatory state. It’s presented with high level of antibody. We wanted to estimated level of vitamin D, level of Thyroid stimulate hormon (TSH) thyroid perioxidase antibody (TPOAb) and thyreoglobulin antibody (TGAb) in our patients with thyroid disturbances. (TD). Materials and Methods: We measured serum levels of vitamin D3 and calcium, TSH ; TGAb, TPOAb with 284 patients: Man (M) N = 79 (27.8%), woman (W) N = 203 (72.2%) with thyroid disease (TD) which included Hypothyroid (Hypo). Hyperthyroid (Hyper) and euthyroid state (Eu) and 349 healthy controls M ; N = 109 (31.2%), W ; N = 240 (68.8%) during the last three years. All who used vitamin D3 or thyroid hormons either thyroid suppresive drugs were excluded from the analysis. We used T-test, analysis of variance, Pearson’s coefficient per Ellis guidelines (2010). Results: The patients with TD had significantly lower values of Vitamin D3 26.18 ± 5.32 nmol/l compared to the control: 60.00 ± 16.58 nmol/l. (P < 0.001). We had 61.3% Hypothyreosis, 23% euthyreosis and 11.6% Hyperthyreosis. We got a very high level od antibodies: TGAb 158 ± 38.7, IU/ ml ; TPOAb 896.5 ± 87.4 IU/ml. Conclusion: We found a significantly lower levels of vitamin D3 in patients with all variance of TD than control. We got statistically significant negative correlation between level of vitamin D and level of ATAb (Pearson correlation coeficient (r) was 0.11 (p = 0.005). All types of thyroid disease showed a low level of vitamin D and a high level thyroid antibodies. We can assume that the normal levels of vitamin D3 could possibly prevent the incidence of inflammatory diseases of the thyroid or better control.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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