Naslov
Prenatal exposure to mercury and child fine motor development in an Eastern Mediterranean cohort

Autori
Barbone, Fabio ; Rosolen, Valentina ; Mariuz, Marika ; Mazej, Darja ; Tratnik, Janja ; Antoniadou, I. ; Špirić, Zdravko ; Valent, Francesca ; Horvat, Milena ; Ronfani, Luca

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
28th Annual Conference of the International Society for Environmental Epidemiology (ISEE) Old and new risks: challenges for environmental epidemiology / - Rim : The International Society for Environmental Epidemiology (ISEE), 2016, P3-141

Skup
28th Annual Conference of the International Society for Environmental Epidemiology (ISEE) Old and new risks: challenges for environmental epidemiology

Mjesto i datum
Rim, Italija, 01.09.2016. - 04.09.2016

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Prenatal exposure; mercury; child; fine motor development; Eastern Mediterranean

Sažetak
Introduction. We argue that the evidence about a relation between maternal total mercury (THg) and child fine motor (FM) neurodevelopmental scores remains insufficient. To fill this gap, we analyzed data from a prospective mother-child cohort recruited in Italy, Slovenia, Croatia and Greece within PHIME, EU Sixth FP. Methods. Study design and rationale of the study is described in Valent F et al J Epidemiol 2013 ; 23(2):146-152. Varying by country, mothers were recruited during pregnancy or at child’s birth. Metals were measured in maternal hair and blood during pregnancy and in umbilical cord blood and breast milk. FM scores were calculated by a psychologist using Bayley III at 18 months. For this analysis we defined the exposure as higher quintiles of mother’s hair THg levels (ng/g) and the outcome as the lowest quintile of the scaled FM score (<=10). Lifestyle, dietary and socioeconomic factors assessed by questionnaires were considered as potential confounders or effect modifiers. Multivariate logistic regression models were run against FM as binary outcome. Results. 2189 mothers were enrolled in the study during pregnancy. 1729 mother-child pairs provided information at child’s birth. Follow-up at 18 months was 85%. Mother’s hair THg quintiles cut-offs were 337, 566, 881, 1456 ng/g. The odds ratio (OR) of an FM score <= 10 for THg ≥ 337 ng/g was 2.04 (95% confidence interval: 1.33-3.21), adjusted for country, sex, breastfeeding duration and earlier introduction of fresh fish in the child’s diet. Results were consistent by country but did not show clear trends. Earlier introduction of fresh fish in child’s diet was linked with higher FM scores (p<0.0245). Conclusions. Absence of a trend for THg level and use of a dichotomous FM outcome variable require caution. However, these results suggest further testing of this hypothesis in existing child cohorts that consider the relation of mercury with FM scores separately from gross psychomotor assessments.

Izvorni jezik
Engleski

Znanstvena područja
Kemijsko inženjerstvo, Rudarstvo, nafta i geološko inženjerstvo, Temeljne medicinske znanosti

POVEZANOST RADA