Naslov
Insights into catalytic mechanism of an enzyme

Autori
Leščić Ašler, Ivana ; Štefanić, Zoran ; Luić, Marija

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, pp prezentacija, znanstveni

Skup
XVI International Conference on Science, Arts and Culture, INTERNATIONAL CONFERENCE ON SESAME In honour of Paolo Budinich

Mjesto i datum
Veli Lošinj, Hrvatska, 29.08.2016. - 02.09.2016

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
X-ray crystallography; synchrotron radiation; enzymes; mechanism of action

Sažetak
Investigation of the mechanism of enzyme action is maybe the most important aspect of protein research. There is a plethora of methods available to study interactions of an enzyme with its substrates and/or inhibitors. Among those, X-ray crystallography stands out by giving the precise 3D picture of enzyme's active site. In principle, the higher the power of X-rays, the higher the resolution of protein's 3D-structure and more details to be observed. Synchrotrons, as the most powerful X- ray sources, provide in many cases atomic resolution 3D-structures and enable detection of details that could otherwise be obscured. The superiority of synchrotron over in-house X- ray source in study of enzyme's active site will be demonstrated on several protein examples.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA