Naslov
Synthesis and evaluation of antibacterial and antioxidant activity of novel 2-phenyl-quinoline analogs derivatized at position 4 with aromatically substituted 4H-1, 2, 4-triazoles

Autori
Verbanac, Donatella ; Malik, Ritu ; Chand, Mahesh ; Kushwaha, Khushbu ; Vashist, Monika ; Matijašić, Mario ; Stepanić, Višnja ; Perić, Mihaela ; Čipčić Paljetak, Hana ; Saso, Luciano ; Jain, Subhash C.

Izvornik
Journal of enzyme inhibition and medicinal chemistry (1475-6366) 31 (2016), Supp. 2; 104-110

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
1 ; 2 ; 4-Triazole-quinoline conjugates ; DFT calculations using DPPH and CAA ; Cytotoxicity Assays

Sažetak
A set of novel quinoline-triazole conjugates (12-31) were synthesized in three steps in good yields starting from 2-phenylquinoline-4-carboxylic acid. All the intermediates, as well as the final 1, 2, 4-triazolyl quinolines were fully characterized by their detailed spectral analysis utilizing different techniques such as IR, 1H NMR, 13C NMR and finally mass spectrometry. All the synthesized compounds were evaluated in vitro for their potential antibacterial activity and their preliminary safety profile was assessed through cytotoxicity assay. Additionally, six selected conjugates were evaluated for their antioxidative properties on the basis of density functional theory (DFT) calculations, using radical scavenging assay (DPPH) and cellular antioxidant assay (CAA). The reported results encourage further investigation of selected compounds and are shading light on their potential pharmacological use.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

POVEZANOST RADA