Naslov
Kinetics of Hydrolysis of Aromatic Hydrazones

Autori
Benković, Tomislav ; Kontrec, Darko ; Budimir, Ana ; Galić, Nives

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, znanstveni

Skup
16th CEEPUS Symposium and Summer School on Bioanalysis

Mjesto i datum
Varšava, Poljska, 06.07.2016. - 15.07.2016

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
aroylhydrazones ; hydrolysis ; spectrophotometry ; chromatography

Sažetak
The kinetics of hydrolysis of compounds 1–12 (Scheme 1) were investigated in acidic and basic methanol/water 1/1 solutions by means of UV-Vis spectrophotometry. Hydrolytic stabilities of 3, 4, 10 and 11 were also studied by HPLC. Hydrolytic products of 3, 4, 5, 7 and 10 in basic media were determined by ESI-MS. The electron-withdrawing substituents decreased the hydrolysis in acidic media, whereas the electron-donating groups (–OH, – OCH3) had the opposite effect. The hydroxyl group at position 4 at salycilidene part of the molecule, and methyl group at azomethine carbon atom, prevented the hydrolysis of hydrazones in basic media. In addition, the hydroxyl groups at position 3 and 5 caused the autooxidation of the hydrolytic products, and conversion of aldehydes to respective quinones. The results obtained by different techniques were in excellent agreement.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA