Naslov
Role of Helicobacter pylori infection in intensive care unit

Autori
Varda-Brkić, Dijana ; Tripković, Vesna ; Žele- Starčević, Lidija ; Bedenić, Branka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Singa Vitae / Vladmir Gašprović - , 2016, 88-88

Skup
Hrvatski simpozij za intenzivnu medicinu

Mjesto i datum
Brijuni, Hrvatska, 18.06.2016. - 21.06.2016

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
Helicobacter pylori; infection; inflammatory response

Sažetak
Helicobacter pylori is gram-negative bacteria that successfully colonize the human stomach, infecting 50% of the world’s population. Many studies have confirmed the role of H. pylori in the development of chronic gastritis, gastric and duodenal ulcer and the ethiological role in the pathogenesis of gastric carcinoma and mucosa-associated lymphoid tissue (MALT) lymphoma. The areas in which H. pylori may have relevance to intensive care unit include a potential role in the pathogenesis of acute gastric stress ulceration, nosocomial infection in healthcare workers and in patients, potential modulatory effect on the systemic disease. The majoriti of ICU patients develop some form of gastrointestinal dysfunction, often as part of the systemic response to injury or infection. In the upper gastrointestinal tract, the major manifestacion of this response is acute stress-related mucosal damage and ulceration, which is associated with increased mortality and morbidity related to bleeding or perforation. The pathogenesis of acute stress ulceration and H. pylori gastritis suggest overlapping mechanisms of gastric mucosal damage, particularly involving neutrophil infiltration and oxygen-derived free radical cytotoxicity. H. pylori may augment stress ulceration incidence and severity. Increased prevalence H. pylori infection in intensive care nurses and patients strongly suggested that H. pylori can transmited in the intensive care environment because of frequent exposure to potentially infected gut contents, such as gastric aspirates, vomitus and feces. H. pylori represent a previously undetected nosocomial infection, and the potential impact on the intensive care patients population could bi significant. In recent years H. pylori infection is reported to be associated with many extragastrointestinal manifestations, such as hematological diseases (idiopathic thrombocytopenic purpura and unexplained iron deficiency anemia), cardiovascular diseases (ischemic heart diseases), neurological disorders (stroke, Parkinson's disease, Alzheimer's disease), some upper respiratory tract diseases, obesity and skin disorders. However, more studies are required to clarify such proposed causal links. Whereas the role of H. pylori in many extraintestinal diseases is not completely proven, the potential role of H. pylori in the modulating of the local and systemic responses still remains likely. Acute stress may increase the local gastric inflammatory response to H. pylori infection, increasing gastric epithelial dysfunction and permeability. In the setting of gastric colonisation with gram-negative bacteria, translocation of bacteria or their products may further aggravate the systemic inflammatory response. We can conclude that, H. pylori infection, the most prevalent bacterial infection in the world, has signficant meaning in ICU.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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