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Pregled bibliografske jedinice broj: 826614

Molecular characterization of class B carbapenemases in advanced stage of dissemination and emergence of class D carbapenemases in Enterobacteriaceae from Croatia

Bedenić, Branka; Sardelić, Sanda; Luxner, Josefa; Bošnjak, Zrinka; Varda-Brkić, Dijana; Lukić-Grlić, Amarela; Mareković, Ivana; Frančula-Zaninović, Sonja; Krilanović, Marija; Šijak, Dorotea et al.
Molecular characterization of class B carbapenemases in advanced stage of dissemination and emergence of class D carbapenemases in Enterobacteriaceae from Croatia // Infection, genetics and evolution, 43 (2016), 74-82 doi:10.1016/j.meegid.2016.05.011 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 826614 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Molecular characterization of class B carbapenemases in advanced stage of dissemination and emergence of class D carbapenemases in Enterobacteriaceae from Croatia

Autori
Bedenić, Branka ; Sardelić, Sanda ; Luxner, Josefa ; Bošnjak, Zrinka ; Varda-Brkić, Dijana ; Lukić-Grlić, Amarela ; Mareković, Ivana ; Frančula-Zaninović, Sonja ; Krilanović, Marija ; Šijak, Dorotea ; Grisold, Andrea ; Zarfel, Gernot

Izvornik
Infection, genetics and evolution (1567-1348) 43 (2016); 74-82

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
VIM-1 ; NDM-1 ; OXA-48 ; Enterobacteriaceae ; resistance

Sažetak
Carbapenemases involved in acquired carbapenem resistance in Enterobacteriaceae belong to Ambler class A serin β-lactamases, class B metallo-β-lactamases (MBL) or class D OXA-48- like β-lactamases. The aim of the present study was to analyse the molecular epidemiology and the mechanisms and routes of spread of class B and class D carbapenemases in Croatia. In total 68 isolates were analyzed. Antibiotic susceptibility was determined by broth microdilution method. PCR was used to detect antibiotic-resistance genes. Genotyping was performed by rep-PCR and MLST. Sixty-five isolates were found to harbour VIM-1 carbapenemase, seven of which were positive also for NDM-1, while two strains harboured only NDM-1. OXA-48 was detected in three isolates, two of which coproduced VIM-1. Thirty-six strains possessed additional CTX-M- 15 β-lactamase whereas 64 were positive for TEM-1. CMY was found in 18 C. freundii isolates and DHA-1 in one E. cloacae isolate. Four different plasmid-incompatibility groups were found: A/C, L/M, N and FIIAs. Unlike C. freundii and E. cloacae, K. pneumoniae showed high diversity of rep-PCR patterns. E. cloacae and C. freundii predominantly belonged to one large clone which was allocated to ST105 and ST24, respectively. Three different types of carbapenemases were identified showing the complexity of CRE in Croatia.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
MZOS-108-1080114-0015 - Mehanizmi rezistencije na antibiotike u Gram-negativnih bakterija (Bedenić, Branka, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Zagreb,
KBC Split,
Klinički bolnički centar Zagreb,
Klinika za dječje bolesti

Profili:

Avatar Url Branka Bedenić (autor)

Avatar Url Ivana Mareković (autor)

Avatar Url Sanda Sardelić (autor)

Avatar Url Amarela Lukić-Grlić (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com

Citiraj ovu publikaciju:

Bedenić, Branka; Sardelić, Sanda; Luxner, Josefa; Bošnjak, Zrinka; Varda-Brkić, Dijana; Lukić-Grlić, Amarela; Mareković, Ivana; Frančula-Zaninović, Sonja; Krilanović, Marija; Šijak, Dorotea et al.
Molecular characterization of class B carbapenemases in advanced stage of dissemination and emergence of class D carbapenemases in Enterobacteriaceae from Croatia // Infection, genetics and evolution, 43 (2016), 74-82 doi:10.1016/j.meegid.2016.05.011 (međunarodna recenzija, članak, znanstveni)
Bedenić, B., Sardelić, S., Luxner, J., Bošnjak, Z., Varda-Brkić, D., Lukić-Grlić, A., Mareković, I., Frančula-Zaninović, S., Krilanović, M. & Šijak, D. (2016) Molecular characterization of class B carbapenemases in advanced stage of dissemination and emergence of class D carbapenemases in Enterobacteriaceae from Croatia. Infection, genetics and evolution, 43, 74-82 doi:10.1016/j.meegid.2016.05.011.
@article{article, author = {Bedeni\'{c}, Branka and Sardeli\'{c}, Sanda and Luxner, Josefa and Bo\v{s}njak, Zrinka and Varda-Brki\'{c}, Dijana and Luki\'{c}-Grli\'{c}, Amarela and Marekovi\'{c}, Ivana and Fran\v{c}ula-Zaninovi\'{c}, Sonja and Krilanovi\'{c}, Marija and \v{S}ijak, Dorotea and Grisold, Andrea and Zarfel, Gernot}, year = {2016}, pages = {74-82}, DOI = {10.1016/j.meegid.2016.05.011}, keywords = {VIM-1, NDM-1, OXA-48, Enterobacteriaceae, resistance}, journal = {Infection, genetics and evolution}, doi = {10.1016/j.meegid.2016.05.011}, volume = {43}, issn = {1567-1348}, title = {Molecular characterization of class B carbapenemases in advanced stage of dissemination and emergence of class D carbapenemases in Enterobacteriaceae from Croatia}, keyword = {VIM-1, NDM-1, OXA-48, Enterobacteriaceae, resistance} }
@article{article, author = {Bedeni\'{c}, Branka and Sardeli\'{c}, Sanda and Luxner, Josefa and Bo\v{s}njak, Zrinka and Varda-Brki\'{c}, Dijana and Luki\'{c}-Grli\'{c}, Amarela and Marekovi\'{c}, Ivana and Fran\v{c}ula-Zaninovi\'{c}, Sonja and Krilanovi\'{c}, Marija and \v{S}ijak, Dorotea and Grisold, Andrea and Zarfel, Gernot}, year = {2016}, pages = {74-82}, DOI = {10.1016/j.meegid.2016.05.011}, keywords = {VIM-1, NDM-1, OXA-48, Enterobacteriaceae, resistance}, journal = {Infection, genetics and evolution}, doi = {10.1016/j.meegid.2016.05.011}, volume = {43}, issn = {1567-1348}, title = {Molecular characterization of class B carbapenemases in advanced stage of dissemination and emergence of class D carbapenemases in Enterobacteriaceae from Croatia}, keyword = {VIM-1, NDM-1, OXA-48, Enterobacteriaceae, resistance} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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