Naslov
The multinational Allergen Immunotherapy Adverse Events Registry (ADER) reveals large heterogeneity in practice

Autori
Mitsias, DI ; Popov, T ; Aggelides, X ; Bogic, M ; Christoff, G ; Deleanu, D ; Dimitrov, Z ; Hoxha, M ; Konstantinou, GN ; Kosnik, M ; Misirligil, Z ; Mungan, D ; Popescu, F ; Popović-Grle, Sanja ; Priftanji, A ; Stipić, Asja ; Stosovic, R ; Tomic-Spiric, V ; Turkalj, M ; Xhixha, F ; Calderon, M ; Papadopoulos, NG ; and the ADER Consortium

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
EAACI Annual Congress: Abstract Book 2016 ; Wiena 11-15 June 2016 / - : EAACI, 2016

Skup
EAACI Annual Congress, Vienna, 2016

Mjesto i datum
Beč, Austrija, 11.06.2016. - 15.06.2016

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Allergen immunotherapy (AIT)

Sažetak
Allergen immunotherapy (AIT) is an effective and safe treatment modality that may modify the natural history of allergic diseases. Despite of published guidelines, there is significant heterogeneity in practicing AIT across different settings. Specialist Allergy Centers from Albania(Al), Bulgaria(Bg), Croatia(Cr), Greece(Gr), Romania(Ro), Serbia(Sb), Slovenia(Sl) and Turkey(Tr)form the Consortium that runs ADER. All AIT courses are uploaded to a secure web application (REDCap) adapted for this purpose.In addition to adverse events (AE), data on epidemiology of allergic diseases and practicing AIT are included. We report data on 2421 patients that undergo a total of 2765 AIT courses. Of these, 1131 are subcutaneous(SCIT), 1260 sublingual(SLIT) and 374 hymenoptera venom AIT(VIT). Age distribution of the patients is right skewed ; most are in the second (n:680) and third (n:526) decade of life. Patients mainly suffer from allergic rhinitis (n:2297), conjunctivitis (n:1055) and asthma (n:1019). Symptomatic treatment consists mainly of antihistamines (68%) and nasal corticosteroids (59%) ; ocular medications (7%) and nasal antihistamines (2%) are rarely used. Of patients that undergo AIT, pollen sensitization is reported in 64% ; grass is by far the most frequent pollen in all countries (91%). In Bg, Cr, Sl, Tr and Ro birch pollen is the second most common sensitization, in Al and Grthat is olive/parietaria and in Sb ragweed/mugwort. The AIT initial phase protocols reflect the heterogeneity in practicing AIT: for SCIT, all but two countries use almost exclusively conventional protocols ; Tr (29% cluster) and Gr (49% cluster/rush) use faster protocols. For VIT, heterogeneity is even greater ; conventional (Bg, Sb), cluster (Tr), rush (Cr, Ro) and ultra-rush (Al, Gr, Sl) protocols are used. The timing of SCIT also varies: in Bg, Gr, Sb and Sl almost exclusively AIT is perennial. In contrast, Al (19%), Cr (30%), Ro (31%) and Tr (26%)use pre- and co-seasonal AITas well. The use of allergoids instead of natural allergen extracts varies as well:in Al, Bg, Gr and Sballergoidsare <6% while in Cr (30%), Tr (58%) and especially Sl (100%) the use is high. Personal preference and experience, allergen diversity andtherapeutic extract availability are some of the factors that lead to heterogeneity of AIT practice in South Eastern Europe. Addressing these and working towards harmonization of AIT mayhelp in improving safety and efficacy.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA