Naslov
Patients with Elevated Homocysteine and Decreased Renal Function Showed an Increased Risk for Cerebrovascular Insult

Autori
Ljubić, Spomenka ; Antal, Ivana ; Jazbec, Ana ; Tomić, Martina ; Piljac, Ante ; Smirčić-Duvnjak, Lea.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Diabetes Care / - , 2016, 435-435

Skup
American Diabetes Association Annual Meeting

Mjesto i datum
New Orleans (LA), Sjedinjene Američke Države, 10.06.2016. - 14.06.2016

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
plasma homocysteine ; renal function ; CVD

Sažetak
We investigated parameters related to cerebrovascular insult (CVI) in relation to previous patient or family history. Lipids, including apolipoprotein (Apo) A1, Apo B and lipoprotein (a) [Lp(a)], parameters of glycaemia, inflammation, and blood pressure (BP) were assessed in 260 patients assigned into groups according to history of CVI, and the presence of glucose intolerance (GI), type 1 (DM1) and type 2 (DM2) diabetes. A control group (CG) was assigned. In all statistical tests (T-test, Mann Whitney test, ANOVA, correlation, logistic regression) α=0.05 was considered statistically significant. Significantly higher values of fasting (FCP) and postprandial C-peptide (PPCP) were observed in siblings whose parents had a history of CVI. Patients with CVI had significantly higher values of homocysteine (HCY) and low-density lipoprotein (LDL), lower albumin/creatinine (A/K) ratio and glomerular filtration rate (GFR). ANOVA revealed significant differences in UA, HCY, and GFR among the groups according to the presence of GI or DM. HCY and UA were significantly higher in patients with DM2 and GI compared to DM1. GFR was lower in DM2 compared to DM1. Patients with DM2 and CVI had significantly higher values of HCY, and decreased A/K ratio and GFR. Women had significantly higher values of PPCP, fibrinogen, high-density lipoprotein and ApoA1 compared to men, whereas fasting blood glucose (FBG), PPBG and uric acid (UA) were higher in men. After logistic regression, stepwise procedure for CVI as a dependent variable, the best model included GFR (OR=0.949 ; 95% CI: 0.925-0.972). In patients with history of CVI GFR correlated significantly with FBG (r=0.87) and Lp(a) (r=0.93) ; UA correlated with LDL (r=0.83). Patients, particularly with DM2, with increased HCY, and decreased renal function could be at increased risk for CVI. CP values were increased in siblings whose parents had a history of CVI. Due to the correlation with GFR, Lp(a) could be connected with CVI.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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