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Pregled bibliografske jedinice broj: 820647

Donor-specific antibodies require preactivated immune system to harm renal transplant

Süsal, Caner; Döhler, Bernd; Ruhenstroth, Andrea; Morath, Christian; Slavcev, Antonij; Fehr, Thomas; Wagner, Eric; Krüger, Bernd; Rees, Margaret; Balen, Sanja et al.
Donor-specific antibodies require preactivated immune system to harm renal transplant // EBioMedicine, 9 (2016), 366-371 doi:10.1016/j.ebiom.2016.06.006 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 820647 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Donor-specific antibodies require preactivated immune system to harm renal transplant

Autori
Süsal, Caner ; Döhler, Bernd ; Ruhenstroth, Andrea ; Morath, Christian ; Slavcev, Antonij ; Fehr, Thomas ; Wagner, Eric ; Krüger, Bernd ; Rees, Margaret ; Balen, Sanja ; Živčić-Ćosić, Stela ; Norman, Douglas J. ; Kuypers, Dirk ; Emonds, Marie-Paule ; Pisarski, Przemyslaw ; Bösmüller, Claudia ; Weimer, Rolf ; Mytilineos, Joannis ; Scherer, Sabine ; Tran, Thuong H. ; Gombos, Petra ; Schemmer, Peter ; Zeier, Martin ; Opelz, Gerhard

Izvornik
EBioMedicine (2352-3964) 9 (2016); 366-371

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Single antigen bead ; HLA antibodies ; donor-specific antibodies ; sCD30 ; kidney transplantation ; graft outcome

Sažetak
Background It is an unresolved issue why some kidney transplant recipients with pretransplant donor-specific HLA antibodies (DSA) show a high transplant failure rate, whereas in other patients DSA do not harm the graft. We investigated whether help from preactivated T-cells might be necessary for DSA to exert a deleterious effect. Methods The impact of pretransplant DSA and immune activation marker soluble CD30 (sCD30) on 3-year graft survival was analyzed in 385 presensitized kidney transplant recipients. Findings A deleterious influence of pretransplant DSA on graft survival was evident only in patients who were positive for the immune activation marker sCD30. In the absence of sCD30 positivity, 3-year graft survival was virtually identical in patients with or without DSA (83·1±3·9% and 84·3±2·8%, P=0·81). A strikingly lower 3-year graft survival rate of 62·1±6·4% was observed in patients who were both sCD30 and DSA positive (HR 2·92, P<0·001). Even in the presence of strong DSA with ≥5, 000 MFI, the 3-year graft survival rate was high if the recipients were sCD30 negative. Interpretation Pretransplant DSA have a significantly deleterious impact on graft survival only in the presence of high pretransplant levels of the activation marker sCD30.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Rijeka,
Klinički bolnički centar Rijeka

Profili:

Avatar Url Sanja Balen (autor)

Avatar Url Stela Živčić-Ćosić (autor)

Poveznice na cjeloviti tekst rada:

doi http www.ncbi.nlm.nih.gov

Citiraj ovu publikaciju:

Süsal, Caner; Döhler, Bernd; Ruhenstroth, Andrea; Morath, Christian; Slavcev, Antonij; Fehr, Thomas; Wagner, Eric; Krüger, Bernd; Rees, Margaret; Balen, Sanja et al.
Donor-specific antibodies require preactivated immune system to harm renal transplant // EBioMedicine, 9 (2016), 366-371 doi:10.1016/j.ebiom.2016.06.006 (međunarodna recenzija, članak, znanstveni)
Süsal, C., Döhler, B., Ruhenstroth, A., Morath, C., Slavcev, A., Fehr, T., Wagner, E., Krüger, B., Rees, M. & Balen, S. (2016) Donor-specific antibodies require preactivated immune system to harm renal transplant. EBioMedicine, 9, 366-371 doi:10.1016/j.ebiom.2016.06.006.
@article{article, author = {S\"{u}sal, Caner and D\"{o}hler, Bernd and Ruhenstroth, Andrea and Morath, Christian and Slavcev, Antonij and Fehr, Thomas and Wagner, Eric and Kr\"{u}ger, Bernd and Rees, Margaret and Balen, Sanja and \v{Z}iv\v{c}i\'{c}-\'{C}osi\'{c}, Stela and Norman, Douglas J. and Kuypers, Dirk and Emonds, Marie-Paule and Pisarski, Przemyslaw and B\"{o}sm\"{u}ller, Claudia and Weimer, Rolf and Mytilineos, Joannis and Scherer, Sabine and Tran, Thuong H. and Gombos, Petra and Schemmer, Peter and Zeier, Martin and Opelz, Gerhard}, year = {2016}, pages = {366-371}, DOI = {10.1016/j.ebiom.2016.06.006}, keywords = {Single antigen bead, HLA antibodies, donor-specific antibodies, sCD30, kidney transplantation, graft outcome}, journal = {EBioMedicine}, doi = {10.1016/j.ebiom.2016.06.006}, volume = {9}, issn = {2352-3964}, title = {Donor-specific antibodies require preactivated immune system to harm renal transplant}, keyword = {Single antigen bead, HLA antibodies, donor-specific antibodies, sCD30, kidney transplantation, graft outcome} }
@article{article, author = {S\"{u}sal, Caner and D\"{o}hler, Bernd and Ruhenstroth, Andrea and Morath, Christian and Slavcev, Antonij and Fehr, Thomas and Wagner, Eric and Kr\"{u}ger, Bernd and Rees, Margaret and Balen, Sanja and \v{Z}iv\v{c}i\'{c}-\'{C}osi\'{c}, Stela and Norman, Douglas J. and Kuypers, Dirk and Emonds, Marie-Paule and Pisarski, Przemyslaw and B\"{o}sm\"{u}ller, Claudia and Weimer, Rolf and Mytilineos, Joannis and Scherer, Sabine and Tran, Thuong H. and Gombos, Petra and Schemmer, Peter and Zeier, Martin and Opelz, Gerhard}, year = {2016}, pages = {366-371}, DOI = {10.1016/j.ebiom.2016.06.006}, keywords = {Single antigen bead, HLA antibodies, donor-specific antibodies, sCD30, kidney transplantation, graft outcome}, journal = {EBioMedicine}, doi = {10.1016/j.ebiom.2016.06.006}, volume = {9}, issn = {2352-3964}, title = {Donor-specific antibodies require preactivated immune system to harm renal transplant}, keyword = {Single antigen bead, HLA antibodies, donor-specific antibodies, sCD30, kidney transplantation, graft outcome} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Emerging Sources Citation Index (ESCI)
  • Scopus
  • MEDLINE

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