Naslov
Etiology of Shizophrenia and therapeutic options

Autori
Rubeša, Gordana ; Gudelj, Lea ; Kubinska, Natalija

Izvornik
Psychiatria Danubina (0353-5053) 23 (2011), 3; 308-315

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
shizofrenija ; etiologija ; terapija
(schizophrenia ; aetiology ; therapy)

Sažetak
Schizophrenia is a complex multifactorial disease with insufficiently known aetiology. There are many hypotheses on the ethiology of SCH, but none of them can fully explain all of the properties of SCH. However, they offer numerous new therapeutic modalities. Biochemical theories find cause of the disease in unbalanced chemical substance in the brain. Dopamine, glutamate, serotonin and acetylcholine are the most important neurotransmitters for the development of schizophrenia. Currently available therapies are mostly based on dopaminergic and serotonergic theories. Majority of scientists nowadays believe in neurodevelopmental and neurodegenerative causes of SCH. Current hypotheses are focused on the study of membrane phospholipids and changes in the central protein synthesis. The theory that encompasses most of the properties of SCH is the hypothesis on reduced central protein synthesis, but it still requires many control studies. Clearly defining the aetiology of schizophrenia would result in significant progress in diagnosis and treatment. Key words: schizophrenia, aetiology, therapy

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA