Pregled bibliografske jedinice broj: 818844
EPR characterisation of the perchlorotriarylmethyl tricarboxylic acid radical and its 13C labelled analogue
EPR characterisation of the perchlorotriarylmethyl tricarboxylic acid radical and its 13C labelled analogue // 7th AAMP MEETING ; Alpe-Adria Medical Physics Meeting: Proceedings / Hršak, Hrvoje ; Budanec, Mirjana (ur.).
Zagreb: Hrvatsko društvo za biomedicinsko inženjerstvo i medicinsku fiziku, 2016. str. 212-215 (poster, međunarodna recenzija, cjeloviti rad (in extenso), ostalo)
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Naslov
EPR characterisation of the perchlorotriarylmethyl tricarboxylic acid radical and its 13C labelled analogue
Autori
Maltar-Strmečki, Nadica ; Elewa, Marwa ; Hinderberger, Dariush ; Imming Peter
Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), ostalo
Izvornik
7th AAMP MEETING ; Alpe-Adria Medical Physics Meeting: Proceedings
/ Hršak, Hrvoje ; Budanec, Mirjana - Zagreb : Hrvatsko društvo za biomedicinsko inženjerstvo i medicinsku fiziku, 2016, 212-215
Skup
7th AAMP MEETING ; Alpe-Adria Medical Physics Meeting ; Zagreb, Croatia, May, 19-21, 2016
Mjesto i datum
Zagreb, Hrvatska, 19.05.2016. - 21.05.2016
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
EPR imaging; spin probe; tetrachlorotriarylmethyl tricarboxylic acid radical
Sažetak
Molecular oxygen plays a key role in cell metabolism. The determination of oxygen level in vitro and in vivo is very important for understanding physiological processes as well as for developing therapy of pathological processes. Electron paramagnetic resonance (EPR) spectroscopy has been shown to be an effective method for measuring the spatial distribution of free radicals in biological systems (in vivo EPR imaging, or EPRI), in which spin labels are used to enhance imaging. EPR oximetry is suitable technique for non-invasive, direct and repeatable oxygen measurements. However, EPRI of molecular oxygen concentrations has been hampered by the lack of suitable spin probes. Triarylmethyl (trityl, TAM) radicals are valuable in vivo probes because of their stability, narrow lines, and sensitivity of their spectroscopic properties to oxygen. Therefore, various trityl radicals have been synthesized. However, signal characteristics depends on the solvent, pH values, temperature and changes in viscosity. Therefore in this work, the tetrachlorotriarylmethyl tricarboxylic acid radical (PTMTC) and its, novel synthesized 13C analogue (13C‐PTMTC) were studied in order to investigate their applicability as EPR oxygen sensors.
Izvorni jezik
Engleski
Znanstvena područja
Fizika, Kemija
