Naslov
UV photolysis of diclofenac in water; kinetics, degradation pathway and environmental aspects

Autori
Kovačić, Marin ; Juretić Perišić, Daria ; Biošić, Martina ; Kušić, Hrvoje ; Babić, Sandra ; Lončarić Božić, Ana

Izvornik
Environmental science and pollution research (0944-1344) 23 (2016), 15; 14908-14917

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
diclofenac ; UV photolysis ; degradation pathway ; biodegradability ; toxicity

Sažetak
In this study, the photolysis behavior of commonly used anti-inflammatory drug diclofenac (DCF) was investigated using UV-C and UV-A irradiation. In that purpose, DCF conversion kinetics, mineralization of organic content, biodegradability, and toxicity were monitored and compared. The results showed different kinetics of DCF conversion regarding the type of UV source applied. However, in both cases, the mineralization extent reached upon complete DCF conversion is rather low (≤10 %), suggesting that the majority of DCF was transformed into by-products. Formation/degradation of main degradation by- products was monitored using high performance liquid chromatography–electrospray ionization tandem mass spectrometry (HPLC–ESI-MS/MS), whereas different profiles were obtained by UV- C and UV-A photolysis. The results of bioassays revealed that biodegradability of DCF solutions remained low through the applied treatments. The toxicity of irradiated DCF solutions was evaluated using Vibrio fischeri. A significant reduction of toxicity, especially in the case of UV-A radiation, was observed upon complete degradation of DCF. In addition to toxicity reduction, calculated Log KOW values of DCF degradation by-products indicate their low potential for bioaccumulation (Log KOW≤ 3) in comparison to the parent substance.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Kemijsko inženjerstvo, Interdisciplinarne tehničke znanosti

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