Naslov
Glycosylation Profile of IgG in Moderate Kidney Dysfunction

Autori
Barrios, Clara ; Zierer, Jonas ; Gudelj, Ivan ; Štambuk, Jerko ; Ugrina, Ivo ; Rodríguez, Eva ; Soler, María José ; Pavić, Tamara ; Šimurina, Mirna ; Keser, Toma ; Pučić-Baković, Maja ; Mangino, Massimo ; Pascual, Julio ; Spector, Tim D. ; Lauc, Gordan ; Menni, Cristina

Izvornik
Journal of the American Society of Nephrology (1046-6673) 27 (2016), 3; 933-941

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
clinical nephrology ; glycation ; renal function decline

Sažetak
Glycans constitute the most abundant and diverse form of the post-translational modifications, and animal studies have suggested the involvement of IgG glycosylation in mechanisms of renal damage. Here, we explored the associations between IgG glycans and renal function in 3274 individuals from the TwinsUK registry. We analyzed the correlation between renal function measured as eGFR and 76 N-glycan traits using linear regressions adjusted for covariates and multiple testing in the larger population. We replicated our results in 31 monozygotic twin pairs discordant for renal function. Results from both analyses were then meta-analyzed. Fourteen glycan traits were associated with renal function in the discovery sample (P<6.5×10(-4)) and remained significant after validation. Those glycan traits belong to three main glycosylation features: galactosylation, sialylation, and level of bisecting N-acetylglucosamine of the IgG glycans. These results show the role of IgG glycosylation in kidney function and provide novel insight into the pathophysiology of CKD and potential diagnostic and therapeutic targets.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Farmacija

POVEZANOST RADA