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Pregled bibliografske jedinice broj: 816969

The Association Between Glycosylation of Immunoglobulin G and Hypertension: A Multiple Ethnic Cross-Sectional Study

Wang, Youxin; Klarić, Lucija; Yu, Xinwei; Thaqi, Kujtim; Dong, Jing; Novokmet, Mislav; Wilson, Jim; Polašek, Ozren; Liu, Youqin; Krištić, Jasminka et al.
The Association Between Glycosylation of Immunoglobulin G and Hypertension: A Multiple Ethnic Cross-Sectional Study // Medicine, 95 (2016), 17; e3379-e3379 doi:10.1097/MD.0000000000003379 (međunarodna recenzija, kratko priopcenje, znanstveni)

CROSBI ID: 816969 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
The Association Between Glycosylation of Immunoglobulin G and Hypertension: A Multiple Ethnic Cross-Sectional Study

Autori
Wang, Youxin ; Klarić, Lucija ; Yu, Xinwei ; Thaqi, Kujtim ; Dong, Jing ; Novokmet, Mislav ; Wilson, Jim ; Polašek, Ozren ; Liu, Youqin ; Krištić, Jasminka ; Ge, Siqi ; Pučić-Baković, Maja ; Wu, Lijuan ; Zhou, Yong ; Ugrina, Ivo ; Song, Manshu ; Zhang, Jie ; Guo, Xiuhua ; Zeng, Qiang ; Rudan, Igor ; Campbell, Harry ; Aulchenko, Yurii ; Lauc, Gordan ; Wang, Wei

Izvornik
Medicine (0025-7974) 95 (2016), 17; E3379-e3379

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kratko priopcenje, znanstveni

Ključne riječi
Immunoglobulin G ; glycosylation ; hypertension

Sažetak
More than half of all known proteins, and almost all membrane and extra-cellular proteins have oligosaccharide structures or glycans attached to them. Defects in glycosylation pathways are directly involved in at least 30 severe human diseases.A multiple center cross-sectional study (China, Croatia, and Scotland) was carried out to investigate the possible association between hypertension and IgG glycosylation. A hydrophilic interaction chromatography of fluorescently labeled glycans was used to analyze N-glycans attached to IgG in plasma samples from a total of 4757 individuals of Chinese Han, Croatian, and Scottish ethnicity.Five glycans (IgG with digalactosylated glycans) significantly differed in participants with prehypertension or hypertension compared to those with normal blood pressure, while additional 17 glycan traits were only significantly differed in participants with hypertension compared to those of normal blood pressure. These glycans were also significant correlated with systolic blood pressure (SBP) or diastolic blood pressure (DBP).The present study demonstrated for the 1st time an association between hypertension and IgG glycome composition. These findings suggest that the individual variation in N-glycosylation of IgG contributes to pathogenesis of hypertension, presumably via its effect on pro- and/or anti-inflammatory pathways.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
GENOS d.o.o.

Profili:

Avatar Url Maja Pučić Baković (autor)

Avatar Url Jasminka Krištić (autor)

Avatar Url Ozren Polašek (autor)

Avatar Url Gordan Lauc (autor)

Avatar Url Igor Rudan (autor)

Avatar Url Mislav Novokmet (autor)

Avatar Url Ivo Ugrina (autor)

Poveznice na cjeloviti tekst rada:

doi journals.lww.com

Citiraj ovu publikaciju:

Wang, Youxin; Klarić, Lucija; Yu, Xinwei; Thaqi, Kujtim; Dong, Jing; Novokmet, Mislav; Wilson, Jim; Polašek, Ozren; Liu, Youqin; Krištić, Jasminka et al.
The Association Between Glycosylation of Immunoglobulin G and Hypertension: A Multiple Ethnic Cross-Sectional Study // Medicine, 95 (2016), 17; e3379-e3379 doi:10.1097/MD.0000000000003379 (međunarodna recenzija, kratko priopcenje, znanstveni)
Wang, Y., Klarić, L., Yu, X., Thaqi, K., Dong, J., Novokmet, M., Wilson, J., Polašek, O., Liu, Y. & Krištić, J. (2016) The Association Between Glycosylation of Immunoglobulin G and Hypertension: A Multiple Ethnic Cross-Sectional Study. Medicine, 95 (17), e3379-e3379 doi:10.1097/MD.0000000000003379.
@article{article, author = {Wang, Youxin and Klari\'{c}, Lucija and Yu, Xinwei and Thaqi, Kujtim and Dong, Jing and Novokmet, Mislav and Wilson, Jim and Pola\v{s}ek, Ozren and Liu, Youqin and Kri\v{s}ti\'{c}, Jasminka and Ge, Siqi and Pu\v{c}i\'{c}-Bakovi\'{c}, Maja and Wu, Lijuan and Zhou, Yong and Ugrina, Ivo and Song, Manshu and Zhang, Jie and Guo, Xiuhua and Zeng, Qiang and Rudan, Igor and Campbell, Harry and Aulchenko, Yurii and Lauc, Gordan and Wang, Wei}, year = {2016}, pages = {e3379-e3379}, DOI = {10.1097/MD.0000000000003379}, keywords = {Immunoglobulin G, glycosylation, hypertension}, journal = {Medicine}, doi = {10.1097/MD.0000000000003379}, volume = {95}, number = {17}, issn = {0025-7974}, title = {The Association Between Glycosylation of Immunoglobulin G and Hypertension: A Multiple Ethnic Cross-Sectional Study}, keyword = {Immunoglobulin G, glycosylation, hypertension} }
@article{article, author = {Wang, Youxin and Klari\'{c}, Lucija and Yu, Xinwei and Thaqi, Kujtim and Dong, Jing and Novokmet, Mislav and Wilson, Jim and Pola\v{s}ek, Ozren and Liu, Youqin and Kri\v{s}ti\'{c}, Jasminka and Ge, Siqi and Pu\v{c}i\'{c}-Bakovi\'{c}, Maja and Wu, Lijuan and Zhou, Yong and Ugrina, Ivo and Song, Manshu and Zhang, Jie and Guo, Xiuhua and Zeng, Qiang and Rudan, Igor and Campbell, Harry and Aulchenko, Yurii and Lauc, Gordan and Wang, Wei}, year = {2016}, pages = {e3379-e3379}, DOI = {10.1097/MD.0000000000003379}, keywords = {Immunoglobulin G, glycosylation, hypertension}, journal = {Medicine}, doi = {10.1097/MD.0000000000003379}, volume = {95}, number = {17}, issn = {0025-7974}, title = {The Association Between Glycosylation of Immunoglobulin G and Hypertension: A Multiple Ethnic Cross-Sectional Study}, keyword = {Immunoglobulin G, glycosylation, hypertension} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

Uključenost u ostale bibliografske baze podataka::


  • DOAJ
  • Europe PMC
  • JCReports
  • Ovid

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