Pregled bibliografske jedinice broj: 814704
Fusion leads to effective segregation of damage during cell division: An analytical treatment
Fusion leads to effective segregation of damage during cell division: An analytical treatment // Journal of theoretical biology, 378 (2015), 47-55 doi:10.1016/j.jtbi.2015.04.022 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 814704 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Fusion leads to effective segregation of damage during cell division: An analytical treatment
Autori
Lade, Steven J. ; Coelho, Miguel ; Tolić, Iva Marija ; Gross, Thilo
Izvornik
Journal of theoretical biology (0022-5193) 378
(2015);
47-55
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
Aggregation ; Damage partition ; Van Kampen expansion ; Directed transport
Sažetak
High levels of cellular damage are associated with impairment of cellular function and cell death. Partitioning the damage into a fraction of cells in the population improves population fitness and survival. We have previously shown that protein aggregates, resulting from misfolded, damaged proteins, fuse with each other leading to damage partitioning during cell division. Here, using an analytical treatment of aggregate fusion in dividing cells we present analytical expressions for two measures of damage partition: aggregate mass partition asymmetry between two dividing cells and standard deviation of total aggregate mass across the population. The scaling laws obtained demonstrate how damage partition may generally depend on characteristics of the cellular processes, facilitating better understanding of damage segregation in biological cells.
Izvorni jezik
Engleski
Znanstvena područja
Fizika, Biologija
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
