Pregled bibliografske jedinice broj: 81412
N-pent-4-enoyl (PNT) Group As a Universal Nucleobase Protector: Applications in the Rapid and Facile Synthesis of Oligonucleotides, Analogs, and Conjugates
N-pent-4-enoyl (PNT) Group As a Universal Nucleobase Protector: Applications in the Rapid and Facile Synthesis of Oligonucleotides, Analogs, and Conjugates // Tetrahedron, 53 (1997), 8; 2731-2750 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 81412 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
N-pent-4-enoyl (PNT) Group As a Universal Nucleobase Protector: Applications in the Rapid and Facile Synthesis of Oligonucleotides, Analogs, and Conjugates
Autori
Iyer, Radhakrishnan P. ; Yu, D. ; Habuš, Ivan ; Ho, Nan-Hui ; Johnson, Suzanne ; Devlin, Theresa ; Jiang, Zhiwei ; Zhou, Wen ; Agrawal, Sudhir
Izvornik
Tetrahedron (0040-4020) 53
(1997), 8;
2731-2750
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
Oligonucleotide synthesis
Sažetak
Rapid synthesis of phosphoric diester and phosphorothioate oligonucleotides in 1 micromol to 1 millimol scale has been achieved using PNT nucleoside phosphoramidites. Furthermore, facile synthesis of mixed backbone oligonucleotides (MBOs) as antisense agents can be carried out using PNT nucleoside phosphoramidites in conjuction with PNT nucleoside H-phosphonates and PNT nucleoside phosphonamidites. The versatility of the PNT group is further demonstrated by its use in the preparation of bioreversible oligonucleotide conjugates.
Izvorni jezik
Engleski
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
Uključenost u ostale bibliografske baze podataka::
- Chemical Abstracts
