Pregled bibliografske jedinice broj: 814041
Changes of central mediators of Wnt signaling DVL1 and DVL3 in human glioblastoma
Changes of central mediators of Wnt signaling DVL1 and DVL3 in human glioblastoma // GlowBrain Workshop "Visualization of molecular markers in the brain"
Zagreb, Hrvatska, 2015. str. 53-53 (poster, domaća recenzija, sažetak, ostalo)
CROSBI ID: 814041 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Changes of central mediators of Wnt signaling DVL1 and DVL3 in human glioblastoma
Autori
Kafka, Anja ; Bačić, Mateja ; Morić, Marina: Skoko, Josip, Pećina-Šlaus, Nives
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo
Izvornik
GlowBrain Workshop "Visualization of molecular markers in the brain"
/ - , 2015, 53-53
Skup
GlowBrain Workshop
Mjesto i datum
Zagreb, Hrvatska, 29.01.2015. - 31.01.2015
Vrsta sudjelovanja
Poster
Vrsta recenzije
Domaća recenzija
Ključne riječi
glioblastoma ; DVL1 ; DVL3 ; wnt signaling
Sažetak
Molecular landscape of human brain tumors still needs elucidation. Glioblastoma are the most aggressive and the most invasive tumors of central nervous system. There are specific signalling pathways involved in disease development, among which is Wnt pathway. Dishevelled (DVL) is cytoplasmatic phosphoprotein, who comes first in downstream cascade from receptor Frizzled (Fz). When the signalization mediated by DVL is disrupted, it results in tumor development and progression. In the present study we aim to investigate the incompletely understood role of Dishevelled (Dvl) gene family, which is considered to be the central hub of wnt signaling Genetic changes of DVL1 and DVL3 were tested by PCR/loss of heterozygosity (LOH) method using D1S468 microsatellite marker for DVL1 gene and D36S1262 for DVL3 gene. Protein expressions and localizations were analyzed by immunohistochemistry.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
HRZZ-IP-2013-11-6625 - Uloga signalnog puta Wnt u epitelno-mezenhimskoj tranziciji (WNT4EMT) (Pećina-Šlaus, Nives) ( CroRIS)
Ustanove:
Medicinski fakultet, Zagreb
Profili:
Anja Kafka
(autor)