Naslov
Stricter microbiological criteria are useful surrogate in estimating the prevalence of nontuberculous mycobacterial pulmonary disease in Croatia

Autori
Jakopovic, Marko ; Jankovic Makek, Mateja ; Sabol, Ivan ; Van Ingen, Jakko ; Zmak, Ljiljana ; Katalinic-Jankovic, Vera ; Ticac, Brigita ; Bulat-Kardum, Ljiljana ; Redzepi, Gzim ; Vranic-Ladavac, Mirna ; Samarzija, Miroslav

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
ERS 2015 : 25th Annual Congress of the European Respiratory Society, 26 - 30 September 2015, Netherlands, Amsterdam. European Respiratory Journal 2015 ; 46 (suppl 59) / - : European Respiratory Society, 2015

Skup
European Respiratory Society International Congress 2015

Mjesto i datum
Amsterdam, Nizozemska, 26.09.2015. - 30.09.2015

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
NTM; ATS criteria; pulmonary disease

Sažetak
Background: nontuberculous mycobacterial pulmonary disease (NTM-PD) is not reportable disease and its prevalence is difficult to assess. Aims and objectives: to assess the use of microbiological and stricter microbiological criteria in the estimation of the NTM-PD in Croatia. Methods: Retrospective analysis of the data from the Croatian national NTM registry. We included all patients with pulmonary NTM (without exclusion of any NTM species) isolated in the period from 2006 through 2013 that also had complete medical records data. Microbiological criteria of the American Thoracic Society (ATS) and stricter microbiological criteria (>3 positive sputum cultures or 1 bronchoscopic or lung biopsy culture + 1 positive sputum culture) were used to establish diagnosis of NTM-PD or NTM colonization, and then correlated to the whole ATS criteria. Results: We identified 368 patients with enough data for firm establishment of diagnosis with both criteria. By comparison of the rate of established NTM-PD diagnosis, we found good correlation between the ATS microbiological criteria and the whole ATS criteria (phi coefficient 0.66 ; 95% CI 0.61 to 0.72, p<0.0001). The strength of correlation increased when we compared stricter microbiological with full ATS criteria (phi coefficient 0.73 ; 95% CI 0.68 to 0.77, p<0.0001). Furthermore, use of ATS microbiological criteria had a positive predictive value (PPV) of NTM-PD of only 59.8%, while stricter microbiological criteria yielded a PPV of 93.3%. Conclusion: In our setting, stricter microbiological criteria may be used as surrogate criteria for laboratory based estimation of national prevalence of NTM-PD.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA