Pregled bibliografske jedinice broj: 813362
Nuclear EGFR Characterize Still Controlled Proliferation Retained in Better Differentiated Clear Cell RCC
Nuclear EGFR Characterize Still Controlled Proliferation Retained in Better Differentiated Clear Cell RCC // Medical Hypotheses, 85 (2015), 2; 183-185 doi:10.1016/j.mehy.2015.04.033. (podatak o recenziji nije dostupan, članak, ostalo)
CROSBI ID: 813362 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Nuclear EGFR Characterize Still Controlled
Proliferation Retained in Better Differentiated
Clear Cell RCC
Autori
Ahel, Juraj ; Dordevic, Gordana ; Markic, Dean ; Mozetic Vladimir ; Spanjol, Josip ; Grahovac, Blazenka ; Stifter, Sanja
Izvornik
Medical Hypotheses (0306-9877) 85
(2015), 2;
183-185
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, ostalo
Ključne riječi
Renal cell carcinoma (RCC) ; EGFR expression ; tumor differentiation
Sažetak
Renal cell carcinoma (RCC) is the most common solid kidney tumor representing 2-3% of all cancers, with the highest frequency occurring in Western countries. There was a worldwide and European annual increase in incidence of approximately 2% although incidence has been stabilized in last few years. One third of the patients already have metastases in the time of the diagnosis with poor prognosis because RCC are radio and chemoresistant. The prognostic value of EGFR over-expression in RCC is a controversial issue that could be explained by different histological types of study tumors and non- standardized criteria for evaluation of expression. Recent evidences points to a new mode of EGFR signaling pathway in which activated EGFR undergoes nuclear translocalization and then, as transcription factor, mediates gene expression and other cellular events required for highly proliferating activities. According to our observations, the membranous expression of EGFR associates with high nuclear grade and poor differentiated tumors. On the other hand, nuclear EGFR expression was high in low nuclear graded and well differentiated tumors with good prognosis. We hypothesize that this mode of EGFR signaling characterizes still controlled proliferation retained in well differentiated RCC with Furhman nuclear grade I or II.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti
POVEZANOST RADA
Ustanove:
Medicinski fakultet, Rijeka
Profili:
Juraj Ahel (autor)
Dean Markić (autor)
Josip Španjol (autor)
Gordana Đorđević (autor)
Sanja Štifter (autor)
Blaženka Grahovac (autor)
Vladimir Mozetič (autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
Uključenost u ostale bibliografske baze podataka::
- BIOSIS Previews (Biological Abstracts)
- CA Search (Chemical Abstracts)
- EMBASE (Excerpta Medica)
- MEDLINE
- METADEX: Metals Science
- Index Medicus
- PubMed
- Elsevier BIOBASE/Current Awareness in Biological Sciences