Pregled bibliografske jedinice broj: 813334
Plasma Levels of Monocyte Chemotactic Protein-1 Are Associated with Clinical Features and Angiogenesis in Patients with Multiple Myeloma
Plasma Levels of Monocyte Chemotactic Protein-1 Are Associated with Clinical Features and Angiogenesis in Patients with Multiple Myeloma // BioMed Research International, / (2016), 7870590-1 doi:10.1155/2016/7870590 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 813334 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Plasma Levels of Monocyte Chemotactic Protein-1
Are Associated with Clinical Features and
Angiogenesis in Patients with Multiple Myeloma
Autori
Valković, Toni ; Babarović, Emina ; Lučin, Ksenija ; Štifter, Sanja ; Aralica, Merica ; Seili-Bekafigo, Irena ; Duletić-Načinović, Antica ; Jonjić, Nives
Izvornik
BioMed Research International (2314-6133)
(2016);
7870590-1
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
MCP-1 ; angiogenesis ; multiple myeloma
Sažetak
The aim of this pilot study was to determine the plasma levels of monocyte chemotactic protein-1 (MCP-1) and possible associations with angiogenesis and the main clinical features of untreated patients with multiple myeloma (MM). ELISA was used to determine plasma MCP-1 levels in 45 newly diagnosed MM patients and 24 healthy controls. The blood vessels were highlighted by immunohistochemical staining, and computer- assisted image analysis was used for more objective and accurate determination of two parameters of angiogenesis: microvessel density (MVD) and total vascular area (TVA). The plasma levels of MCP-1 were compared to these parameters and the presence of anemia, renal dysfunction, and bone lesions. A significant positive correlation was found between plasma MCP-1 concentrations and TVA (p = 0.02). The MCP-1 levels were significantly higher in MM patients with evident bone lesions (p = 0.01), renal dysfunction (p = 0.02), or anemia (p = 0.04). Therefore, our preliminary results found a positive association between plasma MCP-1 levels, angiogenesis (expressed as TVA), and clinical features in patients with MM. However, additional prospective studies with a respectable number of patients should be performed to authenticate these results and establish MCP-1 as a possible target of active treatment.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
POVEZANOST RADA
Projekti:
062-0620095-0078 - Uloga osteopontina u progresiji tumora (Lučin, Ksenija, MZOS ) ( CroRIS)
062-0620095-0079 - Uloga kemokina u patogenezi multiplog mijeloma (Valković, Toni, MZOS ) ( CroRIS)
062-0620095-0082 - REGULACIJSKI ČIMBENICI ANGIOGENEZE U PROGNOZI TUMORA (Jonjić, Nives, MZOS ) ( CroRIS)
062-1081872-0091 - Angiogeneza u agresivnih ne-Hodgkinovih limfoma (Duletić-Načinović, Antica, MZOS ) ( CroRIS)
Ustanove:
Medicinski fakultet, Rijeka,
Klinički bolnički centar Rijeka,
Fakultet zdravstvenih studija u Rijeci
Profili:
Antica Duletić-Načinović
(autor)
Sanja Štifter
(autor)
Emina Babarović
(autor)
Toni Valković
(autor)
Irena Seili-Bekafigo
(autor)
Nives Jonjić
(autor)
Ksenija Jurinović
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE