Naslov
Diagnostic challenge of anti-GQ1b syndrome : differential diagnosis between Miller Fischer syndrome and Bickerstaff ’s brainstem encephalitis

Autori
Sonnenschein, Ivan ; Tomić, Zoran ; Perković, Olivio ; Zadković, Barbara ; Bučuk, Mira

Izvornik
Neurologia Croatica. Supplement (1331-5196) 63 (2014), S; 83-86

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni

Ključne riječi
antiganglioside antibody ; anti-GQ1b syndrome ; Bickerstaff ’s encephalitis ; Guillain-Barré syndrome ; Miller Fisher syndrome

Sažetak
Miller Fisher syndrome (MFS) may be considered as a rare variant of Guillain-Barré syn- drome (GBS). Together with GBS, Bickerstaff ’s brainstem encephalitis and acute ophthalmoparesis without ataxia, MFS is in the group of anti-GQ1b syndrome disorders (anti-GQ1b Sy). Among all GBS variants, MFS is distinctive, presenting with acute symptoms of ophthalmoparesis, ataxia and arefl exia, but without pro- gressive limb weakness as the most characteristic symptom of GBS. MFS is a clinical entity based on typical clinical presentation and defi ned symptoms, and the fi nding of specifi c anti-GQ1b antibodies is not suffi cient for MFS diagnosis. Th e objective of this case report is to demonstrate the diversity of anti-GQ1b Sy clinical presentation. Here we describe a case of a male patient with acute bilateral ophthalmoparesis, mydriasis and unilateral right infranuclear facial nerve palsy, in whom muscle tendon refl exes were preserved and no atax- ia was present. Serum antiganglioside antibody test was positive for anti-GQ1b antibody, confi rming the presupposed diagnosis of MFS. Although MFS is rare, it should be considered in patients with acute develop- ment of ophthalmoplegia. In rare cases of MFS with uncommon presentation, as it was in our case, positive serum antiganglioside antibody test will lead to the right diagnosis.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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