Naslov
NK cells link obesity-induced adipose stress to inflammation and insulin resistance

Autori
Wensveen, Felix M . ; Jelenčić, Vedrana ; Valentić, Sonja ; Šestan, Marko ; Turk Wensveen, Tamara ; Theurich, Sebastian ; Glasner, Ariella ; Mendrila, Davor ; Štimac, Davor ; Wunderlich, F. Thomas ; Brüning, Jens C. ; Mandelboim, Ofer ; Polić, Bojan

Izvornik
Nature immunology (1529-2908) 16 (2015); 376-385

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
NK cells ; diabetes mellitus type 2 ; IFN-gamma

Sažetak
An important cause of obesity-induced insulin resistance is chronic systemic inflammation originating in visceral adipose tissue (VAT). VAT inflammation is associated with the accumulation of proinflammatory macrophages in adipose tissue, but the immunological signals that trigger their accumulation remain unknown. We found that a phenotypically distinct population of tissue-resident natural killer (NK) cells represented a crucial link between obesity-induced adipose stress and VAT inflammation. Obesity drove the upregulation of ligands of the NK cell–activating receptor NCR1 on adipocytes ; this stimulated NK cell proliferation and interferon-γ (IFN-γ) production, which in turn triggered the differentiation of proinflammatory macrophages and promoted insulin resistance. Deficiency of NK cells, NCR1 or IFN-γ prevented the accumulation of proinflammatory macrophages in VAT and greatly ameliorated insulin sensitivity. Thus NK cells are key regulators of macrophage polarization and insulin resistance in response to obesity-induced adipocyte stress.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti

POVEZANOST RADA