Naslov
The effect of glp-1 analogue based therapy on hepatic fat quantity – a prospective observational study

Autori
Duvnjak, Lea ; Majić-Milotić, Dubravka ; Blaslov, Kristina ; Bulum, Tomislav

Izvornik
Diabetologia Croatica (0351-0042) 2014 (2014); 1-5

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
non-alcoholic fatty liver disease; glucagon like recepror-1 agonists; type 2 diabetes

Sažetak
This was an 18-month prospective observational study aiming to assess the effect of treatment with glucagon-like peptide-1 receptor agonists (GLP-1 RAs) on hepatic fat quantity estimated by fatty liver index (FLI) in patients with type 2 diabetes mellitus (T2DM). The study enrolled 75 T2DM patients aged 58±8 years with diabetes duration of 12±6 years, body mass index (BMI) 38.9±5.1 kg/m2 and HbA1c level 8.3±1.2%, randomized to either liraglutide (n=39 ; 48%) or exenatide (n=36 ; 52%) continuing their oral hypoglycemic agents, as well as lipid lowering and antihypertensive therapy. After 18-month follow up, BMI, waist circumference, HbA1c, triglycerides, Creactive protein and FLI were significantly lower compared to baseline values in both groups. However, after inter-group comparison, exenatide was superior to liraglutide in BMI (p=0.001), HbA1c (p=0.026) and FLI (p=0.001) reduction. The introduction of GLP-1 analogues in T2DM therapy may have positive effect on hepatic fat metabolism, with a more favorable effect of exenatide compared to liraglutide, which requires further study evaluation.

Izvorni jezik
Engleski

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