Pregled bibliografske jedinice broj: 804827
Plasma biomarkers of SIRS and MODS associated with canine babesiosis
Plasma biomarkers of SIRS and MODS associated with canine babesiosis // Research in veterinary science, 105 (2016), 222-228 doi:10.1016/j.rvsc.2016.02.011 (međunarodna recenzija, članak, znanstveni)
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Naslov
Plasma biomarkers of SIRS and MODS associated with canine babesiosis
Autori
Kuleš, Josipa ; de Torre-Minguela, Carlos ; Barić Rafaj, Renata ; Gotić, Jelena ; Nižić, Petra ; Ceron, Jose ; Mrljak, Vladimir
Izvornik
Research in veterinary science (0034-5288) 105
(2016);
222-228
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
babesiosis ; multiple organ dysfunction syndrome (MODS) ; proteomics ; systemic inflammatory response syndrome (SIRS)
Sažetak
Canine babesiosis is a tick-borne disease caused by the haemoprotozoan parasites of the genus Babesia. Early detection of systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS) is of major importance in clinical practice for providing information about severity and outcomes of the disease and therapy. Plasma samples were taken at admission from five dogs with uncomplicated babesiosis caused by B. canis canis, five dogs with babesiosis and SIRS, five dogs with babesiosis and MODS, and five healthy dogs. After two-dimensional electrophoresis and capillary reversed - phase liquid chromatography coupled online with tandem mass spectrometry, 68 differentially expressed spots with level of significance P < 0.05 were detected between groups. SIRS in babesiosis was characterised by increases in paraoxonase 1 and apoA-I, whereas MODS with decrease of complement inhibitors leading to prolonged complement activation and decrease of vitamin D binding protein due to haemolysis and activation of the coagulation cascade.
Izvorni jezik
Engleski
Znanstvena područja
Veterinarska medicina
POVEZANOST RADA
Projekti:
HRZZ-IP-2013-11-4135 - Proteomski pristup otkrivanju biomarkera ranog oštećenja bubrega i srca u pasa (BioDog) (Mrljak, Vladimir, HRZZ - 2013-11) ( CroRIS)
Ustanove:
Veterinarski fakultet, Zagreb
Profili:
Vladimir Mrljak
(autor)
Petra Nižić
(autor)
Renata Barić-Rafaj
(autor)
Jelena Gotić
(autor)
Josipa Kuleš
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
Uključenost u ostale bibliografske baze podataka::
- BIOSIS Previews (Biological Abstracts)
- CA Search (Chemical Abstracts)
- MEDLINE
- Current Contents
- SCOPUS