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Pregled bibliografske jedinice broj: 803581

The novel coumarin[3, 2-c]thiophene and its hydroxamic acid and ureido derivatives : synthesis and cytostatic activity evaluations

Wittine, Karlo; Ratkaj, Ivana; Benci, Krešimir; Suhina, Tomislav; Mandić, Leo; Ilić, Nataša; Kraljević Pavelić, Sandra; Pavelić, Krešimir; Mintas, Mladen
The novel coumarin[3, 2-c]thiophene and its hydroxamic acid and ureido derivatives : synthesis and cytostatic activity evaluations // Medicinal chemistry research, 25 (2016), 4; 728-737 doi:10.1007/s00044-016-1523-0 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 803581 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
The novel coumarin[3, 2-c]thiophene and its hydroxamic acid and ureido derivatives : synthesis and cytostatic activity evaluations

Autori
Wittine, Karlo ; Ratkaj, Ivana ; Benci, Krešimir ; Suhina, Tomislav ; Mandić, Leo ; Ilić, Nataša ; Kraljević Pavelić, Sandra ; Pavelić, Krešimir ; Mintas, Mladen

Izvornik
Medicinal chemistry research (1054-2523) 25 (2016), 4; 728-737

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
coumarin[3; 2-c]thiophene; urea; hydroxamic acid; antitumour

Sažetak
In the present paper, we report on the synthesis and in vitro anti-tumour effects of novel hydroxamic acid (compounds 4 and 5) and ureido (compounds 7-11) derivatives containing coumarin[3, 2-c]thiophene moiety. The results of anti-proliferative assays performed on a panel of selected human tumour cell lines revealed stronger concentration-dependent anti-proliferative activity of coumarin[3, 2-c]thiophene (7-11) ureido derivatives in comparison with coumarin[3, 2-c]thiophene hydroxamic acid derivatives (4 and 5). Nevertheless, compounds 7-10 were cytotoxic on normal human fibroblasts as well. Importantly, the ureido derivative 11 and hydroxamic acid derivatives 4 and 5 showed pronounced and selective inhibitory activity towards cervical carcinoma (HeLa) cell line with concomitant low or no cytotoxicity on normal human fibroblasts. These compounds can therefore be considered as potential anti-tumour lead compounds for further structural optimization.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biotehnologija



POVEZANOST RADA

Projekti:
13.11.1.2.01
13.11.1.1.11
125-0982464-2922 - RAZVOJ NOVIH PROLIJEKOVA I LIJEKOVA PROTIV VIRUSA I RAKA (Mintas, Mladen, MZOS ) ( CroRIS)
335-0000000-3532 - Uloga IGF2 i signalni putovi nizvodno u karcinomima pluća čovjeka (Peter-Katalinić, Jasna, MZOS ) ( CroRIS)
335-0982464-2393 - Molekularna obilježja miofibroblasta Dupuytrenove bolesti (Pavelić, Krešimir, MZOS ) ( CroRIS)

Ustanove:
Fakultet kemijskog inženjerstva i tehnologije, Zagreb,
Sveučilište u Rijeci - Odjel za biotehnologiju

Profili:

Avatar Url Krešimir Benci (autor)

Avatar Url Krešimir Pavelić (autor)

Avatar Url Leo Mandić (autor)

Avatar Url Mladen Mintas (autor)

Avatar Url Sandra Kraljević Pavelić (autor)

Avatar Url Ivana Ratkaj (autor)

Avatar Url Karlo Wittine (autor)

Poveznice na cjeloviti tekst rada:

doi link.springer.com link.springer.com

Citiraj ovu publikaciju:

Wittine, Karlo; Ratkaj, Ivana; Benci, Krešimir; Suhina, Tomislav; Mandić, Leo; Ilić, Nataša; Kraljević Pavelić, Sandra; Pavelić, Krešimir; Mintas, Mladen
The novel coumarin[3, 2-c]thiophene and its hydroxamic acid and ureido derivatives : synthesis and cytostatic activity evaluations // Medicinal chemistry research, 25 (2016), 4; 728-737 doi:10.1007/s00044-016-1523-0 (međunarodna recenzija, članak, znanstveni)
Wittine, K., Ratkaj, I., Benci, K., Suhina, T., Mandić, L., Ilić, N., Kraljević Pavelić, S., Pavelić, K. & Mintas, M. (2016) The novel coumarin[3, 2-c]thiophene and its hydroxamic acid and ureido derivatives : synthesis and cytostatic activity evaluations. Medicinal chemistry research, 25 (4), 728-737 doi:10.1007/s00044-016-1523-0.
@article{article, author = {Wittine, Karlo and Ratkaj, Ivana and Benci, Kre\v{s}imir and Suhina, Tomislav and Mandi\'{c}, Leo and Ili\'{c}, Nata\v{s}a and Kraljevi\'{c} Paveli\'{c}, Sandra and Paveli\'{c}, Kre\v{s}imir and Mintas, Mladen}, year = {2016}, pages = {728-737}, DOI = {10.1007/s00044-016-1523-0}, keywords = {coumarin[3, 2-c]thiophene, urea, hydroxamic acid, antitumour}, journal = {Medicinal chemistry research}, doi = {10.1007/s00044-016-1523-0}, volume = {25}, number = {4}, issn = {1054-2523}, title = {The novel coumarin[3, 2-c]thiophene and its hydroxamic acid and ureido derivatives : synthesis and cytostatic activity evaluations}, keyword = {coumarin[3, 2-c]thiophene, urea, hydroxamic acid, antitumour} }
@article{article, author = {Wittine, Karlo and Ratkaj, Ivana and Benci, Kre\v{s}imir and Suhina, Tomislav and Mandi\'{c}, Leo and Ili\'{c}, Nata\v{s}a and Kraljevi\'{c} Paveli\'{c}, Sandra and Paveli\'{c}, Kre\v{s}imir and Mintas, Mladen}, year = {2016}, pages = {728-737}, DOI = {10.1007/s00044-016-1523-0}, keywords = {coumarin[3, 2-c]thiophene, urea, hydroxamic acid, antitumour}, journal = {Medicinal chemistry research}, doi = {10.1007/s00044-016-1523-0}, volume = {25}, number = {4}, issn = {1054-2523}, title = {The novel coumarin[3, 2-c]thiophene and its hydroxamic acid and ureido derivatives : synthesis and cytostatic activity evaluations}, keyword = {coumarin[3, 2-c]thiophene, urea, hydroxamic acid, antitumour} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus

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