Naslov
Effect of propolis on liver functions and diet- induced hyperlipidemia in diet-induced obesity in mice

Autori
Landeka, I., Bertek, N., Jelić, S., Teparić, R., Oršolić, N., Đikić, D.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Bppk of abstracts - 10th Congress of the Croatian society of Biochemistry and Molecular Biology with international participation / Zrinka Kovarik, Jadranka Varljen - Rijeka : Hrvatsko društvo za biokemiju i molekularnu biologiju (HDBMB), 2010, 119-119

Skup
The secret life of biomolecules

Mjesto i datum
Opatija, Hrvatska, 15.09.2010. - 18.09.2010

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
hyperlipidemia ; obesity ; propolis

Sažetak
One of the main environmental factors causing obesity in human is the intake of a high-fat diet. Obesity resulting from an accumulation of visceral adiposity is a primary cause of ˝metabolic syndrome˝ that is the combination of multiple cardiovascular risk factors, including visceral obesity, dyslipidemia, glucose intolerance, and hypertension. Propolis possesses many biological activities, such as antitumor, antioxidant, antimicrobial, anti- inflammatory, and immunomodulatory, among others. A diet-induced obesity animal model has been developed to investigate human obesity. Recent studies have reported that propolis prevented and mitigated diabetes and hypertension, but it remains unclear whether propolis effects the hyperlipidemia and liver functions. In this study we examined the effect of propolis on liver functions and hyperlipidemia induced in a high-fat diet induced obesity mouse model. The propolis extract, at dose of 50 mg/kg body weight/day, was given, by gauge, to mice for 30 days. At the end of the treatment, serum total triglyceride, cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL) and serum enzymes, such as aminotransferase (EC 2.6.1.2), phosphatase (EC 3.1.3.1), dehydrogenase (EC 1.1.1.27) were measured.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija

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