Naslov
Effects of propolis components (naringenin, quercetin, chrysin and caffeic acid) on serum and liver lipids of mice on a high fat diet

Autori
Cancer, Matko ; Hanzić, Nikolina ; Landeka, Irena ; Rogić, Domagoj ; Oršolić, Nada ; Đikić, Domagoj

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of abstracts of the Internacional Conference Medical and Aromatic Plants in Generating of New Values in 21st Century SPECIAL EDITIONS VOL. CXL Department of Natural Sciences and Mathematics Volume 18 / Redžić, Sulejman - Sarajevo : Akademija nauka i umjetosti Bosne i Hercegovine (ANUBiH), 2011, 253-254

ISBN
978-9958-501-68-5

Skup
Internacional Conference Medical and Aromatic Plants in Generating of New Values in 21st Century

Mjesto i datum
Sarajevo, Bosna i Hercegovina, 09.11.2011. - 12.11.2011

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
HDL- cholesterol ; LDL- cholesterol ; oxidative stress ; lipid peroxidation ; propolis

Sažetak
Naringenin, quercetin, chrysin and caffeic acid are potent natural antioxidants and active compounds of propolis. Lipids are a large group of biological compounds. They are insoluble in water and therefore transferred in blood stream as lipoprotein 254 complexes. Lipoproteins are complexes of lipids and apolipoproteins. They are classified according to size, density, and lipid - apolipoprotein ratio: chylomicrons, very low density lipoprotein (VLDL), low density lipoproteins (LDL), intermediate density lipoproteins (IDL) and high density lipoproteins (HDL). Large amounts of LDL are not absorbed in the liver and consumed by macrophages, so they accumulate in the blood stream causing oxidative stress and many pathological conditions. In this study we examined the effects of active compounds of propolis on the composition of serum and liver lipids in mice on high-fat diet. The antioxidants from propolis, namely: naringenin, quercetin, chrysin and caffeic acid were given orally to mice at dose of 50 mg/kg/bw every 48 h, for 30 days. At the end of the treatment serum total triglyceride, cholesterol, HDL, LDL, serum enzymes and metabolites (AST, ALT, ALP i LDH), liver enzymes (MDH and CAT) and MDA product of lipid peroxidation were measured. In our experiment we demonstrated that quercetin, chrysin and caffeic acid have negative effects because they increase the “bad” and decrease “good” cholesterol in serum, and show hepatotoxic effects. On the other hand, no negative effect of naringenin were observed.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija

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