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Pregled bibliografske jedinice broj: 803012

Levels of selected oxidative stress markers in the vitreous and serum of diabetic retinopathy patients


Brzović-Šarić, Vlatka; Landeka, Irena; Šarić, Borna; Barberić, Monika; Andrijašević, Lidija; Cerovski, Branimir; Oršolić, Nada; Đikić, Domagoj
Levels of selected oxidative stress markers in the vitreous and serum of diabetic retinopathy patients // Molecular vision, 21 (2015), 649-664 (međunarodna recenzija, članak, znanstveni)


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Naslov
Levels of selected oxidative stress markers in the vitreous and serum of diabetic retinopathy patients

Autori
Brzović-Šarić, Vlatka ; Landeka, Irena ; Šarić, Borna ; Barberić, Monika ; Andrijašević, Lidija ; Cerovski, Branimir ; Oršolić, Nada ; Đikić, Domagoj

Izvornik
Molecular vision (1090-0535) 21 (2015); 649-664

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
vascular endothelial growth factor (VEGF) ; oxidative stress ; advanced oxidized protein product (AOPP) ; oxidative stress markers

Sažetak
In diabetes, an impaired antioxidant defense system contributes to the development of diabetic retinopathy. The main objective of this paper was to find correlations of oxidative stress parameters within and between the vitreous and serum in patients with type 2 diabetes who had developed proliferative diabetic retinopathy. The study included and compared two groups of patients who underwent vitrectomy: 37 patients with type 2 diabetes and proliferative retinopathy (PDR), and 50 patients with non- diabetic eye disorders (NDED). Vascular endothelial growth factor (VEGF), advanced oxidized protein product (AOPP), and oxidative stress markers (direct lipid hydroperoxidation (LPO), malondialdehyde (MDA), total superoxide dismutase (SOD), and glutathione (GSH)) were measured in the vitreous and serum of both groups and correlated with one another, between humoral compartments and with gender, age, and serum glucose levels. In the vitreous of PDR patients, VEGF, LPO, and MDA (p<0.05) were increased and SOD values were slightly lowered (p<0.05) than in NDED patients. Vitreous AOPP and GSH showed no differences between the groups. In the serum, AOPP, MDA, and SOD were increased (p<0.05) and VEGF was slightly increased (p<0.05) in the PDR group compared to NDED. With regard to gender, similar changes were recorded for both groups, except for the lower serum MDA in males than females in the NDED group. Advanced age showed no significant effect on changes of measured parameters in the vitreous. In the serum, VEGF was positively correlated (p<0.05) and MDA and SOD negatively correlated (p<0.05) with increasing age. Among measured parameters within and between the vitreous and serum, several correlative links occurred in the PDR group that were not present in the NDED group. The most prominent correlation changes were between serum LPO and vitreal LPO, serum SOD and vitreal LPO, serum LPO and serum SOD, and vitreal VEGF and serum SOD. Among the selected oxidative stress markers, SOD and LPO were highly correlative in both the vitreous and serum in PDR compared to patients without metabolic disorders. Their correlations suggested that monitoring their mutual alterations might be informative during PDR development and should be considered in further research.

Izvorni jezik
Engleski



POVEZANOST RADA


Projekti:
119-0000000-1255 - Kemoprevencija rasta tumora polifenolnim sastavnicama (Oršolić, Nada, MZOS ) ( CroRIS)

Ustanove:
Prehrambeno-biotehnološki fakultet, Zagreb,
Medicinski fakultet, Zagreb,
Prirodoslovno-matematički fakultet, Zagreb,
Klinička bolnica "Sveti Duh"

Citiraj ovu publikaciju:

Brzović-Šarić, Vlatka; Landeka, Irena; Šarić, Borna; Barberić, Monika; Andrijašević, Lidija; Cerovski, Branimir; Oršolić, Nada; Đikić, Domagoj
Levels of selected oxidative stress markers in the vitreous and serum of diabetic retinopathy patients // Molecular vision, 21 (2015), 649-664 (međunarodna recenzija, članak, znanstveni)
Brzović-Šarić, V., Landeka, I., Šarić, B., Barberić, M., Andrijašević, L., Cerovski, B., Oršolić, N. & Đikić, D. (2015) Levels of selected oxidative stress markers in the vitreous and serum of diabetic retinopathy patients. Molecular vision, 21, 649-664.
@article{article, author = {Brzovi\'{c}-\v{S}ari\'{c}, Vlatka and Landeka, Irena and \v{S}ari\'{c}, Borna and Barberi\'{c}, Monika and Andrija\v{s}evi\'{c}, Lidija and Cerovski, Branimir and Or\v{s}oli\'{c}, Nada and \DJiki\'{c}, Domagoj}, year = {2015}, pages = {649-664}, keywords = {vascular endothelial growth factor (VEGF), oxidative stress, advanced oxidized protein product (AOPP), oxidative stress markers}, journal = {Molecular vision}, volume = {21}, issn = {1090-0535}, title = {Levels of selected oxidative stress markers in the vitreous and serum of diabetic retinopathy patients}, keyword = {vascular endothelial growth factor (VEGF), oxidative stress, advanced oxidized protein product (AOPP), oxidative stress markers} }
@article{article, author = {Brzovi\'{c}-\v{S}ari\'{c}, Vlatka and Landeka, Irena and \v{S}ari\'{c}, Borna and Barberi\'{c}, Monika and Andrija\v{s}evi\'{c}, Lidija and Cerovski, Branimir and Or\v{s}oli\'{c}, Nada and \DJiki\'{c}, Domagoj}, year = {2015}, pages = {649-664}, keywords = {vascular endothelial growth factor (VEGF), oxidative stress, advanced oxidized protein product (AOPP), oxidative stress markers}, journal = {Molecular vision}, volume = {21}, issn = {1090-0535}, title = {Levels of selected oxidative stress markers in the vitreous and serum of diabetic retinopathy patients}, keyword = {vascular endothelial growth factor (VEGF), oxidative stress, advanced oxidized protein product (AOPP), oxidative stress markers} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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