Pretraga

Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 797325

Allele-specific reprogramming of cancer metabolism by the long non-coding RNA, CCAT2

Redis, Roxana S.; Vela, Luz E.; Lu, Weiqin; Ferreira de Oliveira, Juliana; Ivan, Cristina; Rodriguez-Aguayo, Cristian; Adamoski, Douglas; Pasculli, Barbara; Taguchi, Ayamu; Chen, Yunyun et al.
Allele-specific reprogramming of cancer metabolism by the long non-coding RNA, CCAT2 // Molecular cell, 61 (2016), 4; 520-534 doi:10.1016/j.molcel.2016.01.015 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 797325 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Allele-specific reprogramming of cancer metabolism by the long non-coding RNA, CCAT2

Autori
Redis, Roxana S. ; Vela, Luz E. ; Lu, Weiqin ; Ferreira de Oliveira, Juliana ; Ivan, Cristina ; Rodriguez-Aguayo, Cristian ; Adamoski, Douglas ; Pasculli, Barbara ; Taguchi, Ayamu ; Chen, Yunyun ; Fernandez, Augustin F. ; Valledor, Luis ; Van Roosbroeck, Katrien ; Chang, Samuel ; Shah, Maitri ; Kinnebrew, Garrett ; Han, Leng ; Atlasi, Yaser ; Cheung, Lawrence H. ; Huang, Gilbert Yuanjay ; Monroig, Paloma ; Ramirez, Marc S. ; Catela Ivković, Tina ; Van, Long ; Ling, Hui ; Gafa, Roberta ; Kapitanović, Sanja ; Lanza, Giovanni ; Bankson, James A. ; Huang, Peng ; Lai, Stephen Y. ; Bast, Robert C. ; Rosenblum, Michael G. ; Radovich, Milan ; Ivan, Mircea ; Bartholomeusz, Geoffrey ; Liang, Han ; Fraga, Mario F. ; Widger, William R. ; Hanash, Samir ; Berindan-Neagoe, Ioana ; Lopez-Berenstein, Gabriel ; Ambrosio, Andre LB ; Gomes Dias, Sandra M. ; Calin, George A.

Izvornik
Molecular cell (1097-2765) 61 (2016), 4; 520-534

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
CCAT2; long ncRNA; GLS; cancer metabolism; glutamine; CFIm25; rs6983267 SNP; 8q24

Sažetak
Altered energy metabolism is a cancer hallmark as malignant cells tailor their metabolic pathways to meet their energy requirements. Glucose and glutamine are the major nutrients that fuel cellular metabolism and the pathways utilizing these nutrients are often altered in cancer. Here, we show that the long ncRNA CCAT2, located at the 8q24 amplicon on cancer risk associated rs6983267 SNP, regulates cancer metabolism in vitro and in vivo, in an allele-specific manner by binding the Cleavage Factor I (CFIm) complex with distinct affinities for the two subunits (CFIm25 and CFIm68). The CCAT2 interaction with the CFIm complex fine-tunes the alternative splicing of Glutaminase (GLS) by selecting the poly(A) site in intron 14 of the precursor mRNA. These findings uncover a complex, allele-specific regulatory mechanism of cancer metabolism orchestrated by alleles of a long ncRNA.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
098-0982464-2508 - Molekularna genetika i farmakogenetika gastrointestinalnih tumora (Kapitanović, Sanja, MZOS ) ( CroRIS)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Sanja Kapitanović (autor)

Avatar Url Tina Catela Ivković (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com dx.doi.org

Citiraj ovu publikaciju:

Redis, Roxana S.; Vela, Luz E.; Lu, Weiqin; Ferreira de Oliveira, Juliana; Ivan, Cristina; Rodriguez-Aguayo, Cristian; Adamoski, Douglas; Pasculli, Barbara; Taguchi, Ayamu; Chen, Yunyun et al.
Allele-specific reprogramming of cancer metabolism by the long non-coding RNA, CCAT2 // Molecular cell, 61 (2016), 4; 520-534 doi:10.1016/j.molcel.2016.01.015 (međunarodna recenzija, članak, znanstveni)
Redis, R., Vela, L., Lu, W., Ferreira de Oliveira, J., Ivan, C., Rodriguez-Aguayo, C., Adamoski, D., Pasculli, B., Taguchi, A. & Chen, Y. (2016) Allele-specific reprogramming of cancer metabolism by the long non-coding RNA, CCAT2. Molecular cell, 61 (4), 520-534 doi:10.1016/j.molcel.2016.01.015.
@article{article, author = {Redis, Roxana S. and Vela, Luz E. and Lu, Weiqin and Ferreira de Oliveira, Juliana and Ivan, Cristina and Rodriguez-Aguayo, Cristian and Adamoski, Douglas and Pasculli, Barbara and Taguchi, Ayamu and Chen, Yunyun and Fernandez, Augustin F. and Valledor, Luis and Van Roosbroeck, Katrien and Chang, Samuel and Shah, Maitri and Kinnebrew, Garrett and Han, Leng and Atlasi, Yaser and Cheung, Lawrence H. and Huang, Gilbert Yuanjay and Monroig, Paloma and Ramirez, Marc S. and Catela Ivkovi\'{c}, Tina and Van, Long and Ling, Hui and Gafa, Roberta and Kapitanovi\'{c}, Sanja and Lanza, Giovanni and Bankson, James A. and Huang, Peng and Lai, Stephen Y. and Bast, Robert C. and Rosenblum, Michael G. and Radovich, Milan and Ivan, Mircea and Bartholomeusz, Geoffrey and Liang, Han and Fraga, Mario F. and Widger, William R. and Hanash, Samir and Berindan-Neagoe, Ioana and Lopez-Berenstein, Gabriel and Ambrosio, Andre LB and Gomes Dias, Sandra M. and Calin, George A.}, year = {2016}, pages = {520-534}, DOI = {10.1016/j.molcel.2016.01.015}, keywords = {CCAT2, long ncRNA, GLS, cancer metabolism, glutamine, CFIm25, rs6983267 SNP, 8q24}, journal = {Molecular cell}, doi = {10.1016/j.molcel.2016.01.015}, volume = {61}, number = {4}, issn = {1097-2765}, title = {Allele-specific reprogramming of cancer metabolism by the long non-coding RNA, CCAT2}, keyword = {CCAT2, long ncRNA, GLS, cancer metabolism, glutamine, CFIm25, rs6983267 SNP, 8q24} }
@article{article, author = {Redis, Roxana S. and Vela, Luz E. and Lu, Weiqin and Ferreira de Oliveira, Juliana and Ivan, Cristina and Rodriguez-Aguayo, Cristian and Adamoski, Douglas and Pasculli, Barbara and Taguchi, Ayamu and Chen, Yunyun and Fernandez, Augustin F. and Valledor, Luis and Van Roosbroeck, Katrien and Chang, Samuel and Shah, Maitri and Kinnebrew, Garrett and Han, Leng and Atlasi, Yaser and Cheung, Lawrence H. and Huang, Gilbert Yuanjay and Monroig, Paloma and Ramirez, Marc S. and Catela Ivkovi\'{c}, Tina and Van, Long and Ling, Hui and Gafa, Roberta and Kapitanovi\'{c}, Sanja and Lanza, Giovanni and Bankson, James A. and Huang, Peng and Lai, Stephen Y. and Bast, Robert C. and Rosenblum, Michael G. and Radovich, Milan and Ivan, Mircea and Bartholomeusz, Geoffrey and Liang, Han and Fraga, Mario F. and Widger, William R. and Hanash, Samir and Berindan-Neagoe, Ioana and Lopez-Berenstein, Gabriel and Ambrosio, Andre LB and Gomes Dias, Sandra M. and Calin, George A.}, year = {2016}, pages = {520-534}, DOI = {10.1016/j.molcel.2016.01.015}, keywords = {CCAT2, long ncRNA, GLS, cancer metabolism, glutamine, CFIm25, rs6983267 SNP, 8q24}, journal = {Molecular cell}, doi = {10.1016/j.molcel.2016.01.015}, volume = {61}, number = {4}, issn = {1097-2765}, title = {Allele-specific reprogramming of cancer metabolism by the long non-coding RNA, CCAT2}, keyword = {CCAT2, long ncRNA, GLS, cancer metabolism, glutamine, CFIm25, rs6983267 SNP, 8q24} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE
  • Nature Index

Citati:

    Altmetrijski pokazatelji:


    Podijeli:





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font
    CROSBI koristi kolačiće (cookies) kako bi poboljšao funkcionalnost stranice.