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Pregled bibliografske jedinice broj: 796164

Cocoa polyphenols exhibit antioxidant, anti-inflammatory, anticancerogenic and anti-necrotic activity in carbon tetrachloride-intoxicated mice

Giacometti, Jasminka; Muhvić, Damir; Pavletić, Adriano; Đudarić, Luka
Cocoa polyphenols exhibit antioxidant, anti-inflammatory, anticancerogenic and anti-necrotic activity in carbon tetrachloride-intoxicated mice // Journal of Functional Foods, 23 (2016), 177-187 doi:10.1016/j.jff.2016.02.036 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 796164 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Cocoa polyphenols exhibit antioxidant, anti-inflammatory, anticancerogenic and anti-necrotic activity in carbon tetrachloride-intoxicated mice

Autori
Giacometti, Jasminka ; Muhvić, Damir ; Pavletić, Adriano ; Đudarić, Luka

Izvornik
Journal of Functional Foods (1756-4646) 23 (2016); 177-187

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Cocoa polyphenols; Epicatechin; Liver damage; Antioxidants; Inflammation; Oxidative stress

Sažetak
The therapeutic effects of cocoa polyphenols on acute carbon tetrachloride (CCl4) -intoxicated mice were investigated. After determination polyphenols profile in the cocoa extract (CE), CE at a dose of 34.5 mg/kg and epicatechin (EC) at a dose of 2.24 mg/kg were intraperitoneally (i.p.) administered to BALB/cN mice following CCl4-treatment. CE and EC post-treatments suppressed hepatotoxicity and inflammation, ameliorated serum markers of liver injury, returned blood lactate and glucose levels to normal, stimulated synthesis and storage of liver glycogen, and modulated glucose metabolism imbalance induced by CCl4. Cocoa polyphenols also exhibited early stage antifibrotic and anticarcinogenic effects. They affected beneficially mitochondrial functionality acting on dysfunction in mitochondrial respiration caused by CCl4 and antioxidants regulation at subcellular levels.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti

Napomena
This work has been supported by the University of Rijeka under the project number 13.11.1.2.02.



POVEZANOST RADA

Projekti:
13.11.1.2.02
335-0000000-0221 - Potencijalna primjena kakao polifenola u inhibiciji fibroze jetre (Giacometti, Jasminka, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Rijeka,
Sveučilište u Rijeci - Odjel za biotehnologiju

Profili:

Avatar Url Luka Đudarić (autor)

Avatar Url Damir Muhvić (autor)

Avatar Url Jasminka Giacometti (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com dx.doi.org

Citiraj ovu publikaciju:

Giacometti, Jasminka; Muhvić, Damir; Pavletić, Adriano; Đudarić, Luka
Cocoa polyphenols exhibit antioxidant, anti-inflammatory, anticancerogenic and anti-necrotic activity in carbon tetrachloride-intoxicated mice // Journal of Functional Foods, 23 (2016), 177-187 doi:10.1016/j.jff.2016.02.036 (međunarodna recenzija, članak, znanstveni)
Giacometti, J., Muhvić, D., Pavletić, A. & Đudarić, L. (2016) Cocoa polyphenols exhibit antioxidant, anti-inflammatory, anticancerogenic and anti-necrotic activity in carbon tetrachloride-intoxicated mice. Journal of Functional Foods, 23, 177-187 doi:10.1016/j.jff.2016.02.036.
@article{article, author = {Giacometti, Jasminka and Muhvi\'{c}, Damir and Pavleti\'{c}, Adriano and \DJudari\'{c}, Luka}, year = {2016}, pages = {177-187}, DOI = {10.1016/j.jff.2016.02.036}, keywords = {Cocoa polyphenols, Epicatechin, Liver damage, Antioxidants, Inflammation, Oxidative stress}, journal = {Journal of Functional Foods}, doi = {10.1016/j.jff.2016.02.036}, volume = {23}, issn = {1756-4646}, title = {Cocoa polyphenols exhibit antioxidant, anti-inflammatory, anticancerogenic and anti-necrotic activity in carbon tetrachloride-intoxicated mice}, keyword = {Cocoa polyphenols, Epicatechin, Liver damage, Antioxidants, Inflammation, Oxidative stress} }
@article{article, author = {Giacometti, Jasminka and Muhvi\'{c}, Damir and Pavleti\'{c}, Adriano and \DJudari\'{c}, Luka}, year = {2016}, pages = {177-187}, DOI = {10.1016/j.jff.2016.02.036}, keywords = {Cocoa polyphenols, Epicatechin, Liver damage, Antioxidants, Inflammation, Oxidative stress}, journal = {Journal of Functional Foods}, doi = {10.1016/j.jff.2016.02.036}, volume = {23}, issn = {1756-4646}, title = {Cocoa polyphenols exhibit antioxidant, anti-inflammatory, anticancerogenic and anti-necrotic activity in carbon tetrachloride-intoxicated mice}, keyword = {Cocoa polyphenols, Epicatechin, Liver damage, Antioxidants, Inflammation, Oxidative stress} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus

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