Pregled bibliografske jedinice broj: 790232
Quantitative proteomics reveals that stathmin - a microtubule destabilising protein – is highly enriched in the developing corticospinal system
Quantitative proteomics reveals that stathmin - a microtubule destabilising protein – is highly enriched in the developing corticospinal system // Book of abstracts of the FENS Featured Regional Meeting 2015
Solun, Grčka, 2015. str. 52-52 (poster, međunarodna recenzija, sažetak, ostalo)
CROSBI ID: 790232 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Quantitative proteomics reveals that stathmin - a microtubule destabilising protein – is highly enriched in the developing corticospinal system
Autori
Fuller, Heidi R. ; Slade, Robert ; Jovanov- Milošević, Nataša ; Babić, Mirjana ; Sedmak, Goran ; Šimić, Goran ; Fuszard, Matthew A. ; Shirran, Sally L. ; Botting, Catherine H. ; Gates, Monte A.
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo
Izvornik
Book of abstracts of the FENS Featured Regional Meeting 2015
/ - , 2015, 52-52
Skup
FENS Featured Regional Meeting 2015
Mjesto i datum
Solun, Grčka, 07.10.2015. - 10.10.2015
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
Corticospinal tract; stathmin; developing brain
Sažetak
The mammalian corticospinal tract (CST) is the longest efferent axonal projection in the central nervous system, originating from upper motor neurons in layer V of the cortex. Little, though, is known about the proteins that are important to the growth of corticospinal neurons down the spinal cord. This is unfortunate because regeneration of the CST is of great therapeutic importance. There are an estimated 6, 500 cases of spinal cord injury (SCI) per year in Western Europe, and between 100, 000-200, 000 incidences worldwide. One hope is that by identifying key intracellular and extracellular proteins involved in the development and growth of the corticospinal system, the regeneration of the mature CST might be enhanced by manipulating these developmental constituents. The aim of this study, therefore, was to conduct a comprehensive temporal and spatial quantitative proteomics analysis of the rat CST during its formation.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
HRZZ-09/16 - Otkrivanje i praćenje bioloških biljega radi rane terapijske intervencije u Alzheimerovoj bolesti (Šimić, Goran, HRZZ ) ( CroRIS)
IP-2014-09-9730 - Hiperfosforilacija, agregacija i transsinaptički prijenos tau proteina u Alzheimerovoj bolesti: analiza likvora i ispitivanje potencijalnih neuroprotektivnih spojeva (ALZTAUPROTECT) (Šimić, Goran) ( CroRIS)
Ustanove:
Medicinski fakultet, Zagreb
Profili:
Mirjana Babić Leko
(autor)
Goran Šimić
(autor)
Nataša Jovanov Milošević
(autor)
Goran Sedmak
(autor)