Pregled bibliografske jedinice broj: 790225
Macro and microelements and Alzheimer’s disease protein biomarkers in cerebrospinal fluid
Macro and microelements and Alzheimer’s disease protein biomarkers in cerebrospinal fluid // JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY / Jurasović, Jasna ; Aschner, Michael (ur.).
Srebreno, Hrvatska: Elsevier, 2015. str. 7-7 (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 790225 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Macro and microelements and Alzheimer’s disease protein biomarkers in cerebrospinal fluid
Autori
Babić Leko, Mirjana ; Borovečki, Fran ; Jurasović, Jasna ; Orct, Tatjana ; Hof, Patrick R. ; Šimić, Goran
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
/ Jurasović, Jasna ; Aschner, Michael - : Elsevier, 2015, 7-7
Skup
Recent Advances in Trace Element Research in Health and Disease
Mjesto i datum
Srebreno, Hrvatska, 18.10.2015. - 22.10.2015
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
Alzheimer's disease; mild cognitive impairment; biomarkers; cerebrospinal fluid; macro and microelements
Sažetak
The homeostasis of macro and microelements is altered in the brain of patients suffering from Alzheimer’s disease (AD). In this study we analysed 24 macro and microelements in cerebrospinal fluid (CSF) and correlated its concentration with AD protein biomarkers (Aβ1- 42, t-tau, p-tau181, p-tau199, p-tau231 and VILIP-1) in CSF of 63 patients with AD, 31 with mild cognitive impairment (MCI), and 11 healthy controls (HC). A significantly negative correlation was found between Aβ1-42 and Co, while significantly positive correlations were obtained between t-tau and Li, As, Se, Sr ; p- tau181 and B, Na, Mg, S, K, Ca, Cr, Fe, Co, Mn, Ni, Cu, Zn, As, Se, Mo, Tl, Hg ; p-tau199 and B, Na, Mg, S, K, Ca, Cr, Fe, Co, Mn, Cu, As, Se, Sr, Mo, Cd, Ba, Tl, Hg ; p-tau231 and Li, B, Na, Mg, S, K, Cr, Fe, Co, Mn, Ni, Cu, Zn, Se, Sr, Mo, Tl, Hg ; VILIP-1 and Li, B, Na, Mg, S, K, Ca, Cr, Fe, Co, Mn, Ni, Cu, Zn, As, Se, Sr, Mo, Cd, Ba, Tl, Hg. Although possible explanation of altered levels of elements in AD brain will await identification of their environmental sources or detection of their release from brain tissue due to cell death, these results suggest CSF element analysis potential as marker of AD neurodegenerative process.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
HRZZ-09/16 - Otkrivanje i praćenje bioloških biljega radi rane terapijske intervencije u Alzheimerovoj bolesti (Šimić, Goran, HRZZ ) ( CroRIS)
108-1081870-1942 - Fosforilacija tau proteina u razvitku i Alzheimerovoj bolesti (Šimić, Goran, MZOS ) ( CroRIS)
IP-2014-09-9730 - Hiperfosforilacija, agregacija i transsinaptički prijenos tau proteina u Alzheimerovoj bolesti: analiza likvora i ispitivanje potencijalnih neuroprotektivnih spojeva (ALZTAUPROTECT) (Šimić, Goran) ( CroRIS)
Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb
Profili:
Mirjana Babić Leko
(autor)
Tatjana Orct
(autor)
Goran Šimić
(autor)
Mirjana Babić
(autor)
Fran Borovečki
(autor)
Jasna Jurasović
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE