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Pregled bibliografske jedinice broj: 789813

Second reduced intensity conditioning allogeneic transplant as a rescue strategy for acute leukaemia patients who relapse after an initial RIC allogeneic transplantation : analysis of risk factors and treatment outcomes

Vrhovac, Radovan; Labopin, Myriam; Ciceri, Fabio; Finke, Juergen; Holler, Ernst; Tischer, Johanna; Lioure, Bruno; Gribben, John; Kanz, Lothar; Blaise, Didier et al.
Second reduced intensity conditioning allogeneic transplant as a rescue strategy for acute leukaemia patients who relapse after an initial RIC allogeneic transplantation : analysis of risk factors and treatment outcomes // Bone marrow transplantation (Basingstoke), 51 (2016), 2; 186-193 doi:1038/bmt.2015.221 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 789813 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Second reduced intensity conditioning allogeneic transplant as a rescue strategy for acute leukaemia patients who relapse after an initial RIC allogeneic transplantation : analysis of risk factors and treatment outcomes

Autori
Vrhovac, Radovan ; Labopin, Myriam ; Ciceri, Fabio ; Finke, Juergen ; Holler, Ernst ; Tischer, Johanna ; Lioure, Bruno ; Gribben, John ; Kanz, Lothar ; Blaise, Didier ; Dreger, Peter ; Held, Gerhard ; Arnold, Renate ; Nagler, Arnon ; Mohty, Mohamad

Izvornik
Bone marrow transplantation (Basingstoke) (0268-3369) 51 (2016), 2; 186-193

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
allogeneic stem cell transplantation; reduced intensity conditioning; acute leukemia; relapse

Sažetak
Limited therapeutic options are available after relapse of acute leukaemia following first reduced intensity conditioning haematopoietic stem cell transplantation (RIC1). A retrospective study on European Society for Blood and Marrow Transplantation (EBMT) registry data was performed on 234 adult patients with acute leukaemia who received a second RIC transplantation (RIC2) from 2000 to 2012 as a salvage treatment for relapse following RIC1. At the time of RIC2, 167 patients (71.4%) had relapsed or refractory disease, 49 (20.9%) were in second CR and 18 (7.7%) in third or higher CR. With a median follow-up of 21 (1.5- 79) months after RIC2, 51 patients are still alive. At 2 years, the cumulative incidence of non-relapse mortality (NRM), relapse incidence (RI), leukaemia-free survival (LFS) and overall survival (OS) were 22.4% (95% confidence interval (CI): 17-28.4), 63.9% (56.7-70.1), 14.6% (8.8- 18.5) and 20.5% (14.9-26.1), respectively. In patients with acute myelogenous, biphenotypic and undifferentiated leukaemia (representing 89.8% of all patients), duration of remission following RIC1 >225 days, presence of CR at RIC2, patient's Karnofsky performance status >80 at RIC2 and non- myeloablative conditioning were found to be the strongest predictors of patients' favourable outcome

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

Napomena
On behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation (EBMT).



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb

Profili:

Avatar Url Radovan Vrhovac (autor)

Poveznice na cjeloviti tekst rada:

doi www.nature.com

Citiraj ovu publikaciju:

Vrhovac, Radovan; Labopin, Myriam; Ciceri, Fabio; Finke, Juergen; Holler, Ernst; Tischer, Johanna; Lioure, Bruno; Gribben, John; Kanz, Lothar; Blaise, Didier et al.
Second reduced intensity conditioning allogeneic transplant as a rescue strategy for acute leukaemia patients who relapse after an initial RIC allogeneic transplantation : analysis of risk factors and treatment outcomes // Bone marrow transplantation (Basingstoke), 51 (2016), 2; 186-193 doi:1038/bmt.2015.221 (međunarodna recenzija, članak, znanstveni)
Vrhovac, R., Labopin, M., Ciceri, F., Finke, J., Holler, E., Tischer, J., Lioure, B., Gribben, J., Kanz, L. & Blaise, D. (2016) Second reduced intensity conditioning allogeneic transplant as a rescue strategy for acute leukaemia patients who relapse after an initial RIC allogeneic transplantation : analysis of risk factors and treatment outcomes. Bone marrow transplantation (Basingstoke), 51 (2), 186-193 doi:1038/bmt.2015.221.
@article{article, author = {Vrhovac, Radovan and Labopin, Myriam and Ciceri, Fabio and Finke, Juergen and Holler, Ernst and Tischer, Johanna and Lioure, Bruno and Gribben, John and Kanz, Lothar and Blaise, Didier and Dreger, Peter and Held, Gerhard and Arnold, Renate and Nagler, Arnon and Mohty, Mohamad}, year = {2016}, pages = {186-193}, DOI = {1038/bmt.2015.221}, keywords = {allogeneic stem cell transplantation, reduced intensity conditioning, acute leukemia, relapse}, journal = {Bone marrow transplantation (Basingstoke)}, doi = {1038/bmt.2015.221}, volume = {51}, number = {2}, issn = {0268-3369}, title = {Second reduced intensity conditioning allogeneic transplant as a rescue strategy for acute leukaemia patients who relapse after an initial RIC allogeneic transplantation : analysis of risk factors and treatment outcomes}, keyword = {allogeneic stem cell transplantation, reduced intensity conditioning, acute leukemia, relapse} }
@article{article, author = {Vrhovac, Radovan and Labopin, Myriam and Ciceri, Fabio and Finke, Juergen and Holler, Ernst and Tischer, Johanna and Lioure, Bruno and Gribben, John and Kanz, Lothar and Blaise, Didier and Dreger, Peter and Held, Gerhard and Arnold, Renate and Nagler, Arnon and Mohty, Mohamad}, year = {2016}, pages = {186-193}, DOI = {1038/bmt.2015.221}, keywords = {allogeneic stem cell transplantation, reduced intensity conditioning, acute leukemia, relapse}, journal = {Bone marrow transplantation (Basingstoke)}, doi = {1038/bmt.2015.221}, volume = {51}, number = {2}, issn = {0268-3369}, title = {Second reduced intensity conditioning allogeneic transplant as a rescue strategy for acute leukaemia patients who relapse after an initial RIC allogeneic transplantation : analysis of risk factors and treatment outcomes}, keyword = {allogeneic stem cell transplantation, reduced intensity conditioning, acute leukemia, relapse} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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