Pregled bibliografske jedinice broj: 788766
Dietary effect on c-peptide preservation in type 1 diabetic pregnant women
Dietary effect on c-peptide preservation in type 1 diabetic pregnant women // Gynaecologia et perinatologia : journal for gynaecology, perinatology, reproductive medicine and ultrasonic diagnostics, 24 (2015), 1; 31-36 (međunarodna recenzija, pregledni rad, znanstveni)
CROSBI ID: 788766 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Dietary effect on c-peptide preservation in type 1 diabetic pregnant women
Autori
Đelmiš, Josip ; Radončić, Erden ; Horvatiček, Marina ; Ivanišević, Marina.
Izvornik
Gynaecologia et perinatologia : journal for gynaecology, perinatology, reproductive medicine and ultrasonic diagnostics (1330-0091) 24
(2015), 1;
31-36
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni
Ključne riječi
pregnancy; type 1 diabetes mellitus; C-peptide; nicotinamide; omega-3 fatty acids; vitamins D and E
Sažetak
Insulin is the main hormone in the regulation of glucose metabolism. Insulin is synthesized in the Langerhans islet β-cells as the proinsulin precursor, from which C-peptide and insulin are formed by proteolytic cleavage. In patients with type 1 diabetes mellitus (DM-1), complex interplay of genetic, exogenous ad autonomic factors leads to selective destruction of pancreatic β-cells, thus compromising insulin synthesis and secretion. Patients with DM-1 can produce exogenous insulin to a certain extent, however, insulin secretion undergoes gradual reduction due to selective destruction of β-cell function. Both C-peptide and insulin are secreted to portal circulation in equimolar amounts. There is an association of elevated C-peptide concentration with great reduction of hypoglycemic episodes, HbA1c values and microvascular complications. Studies have demonstrated that vitamins D and E, nicotinamide and polyunsaturated fatty acids (omega-3 fatty acids) may have protective effects in DM-1. Our investigations showed C-peptide to increase in both healthy and DM-1 pregnant women. This review article describes the impact of pregnancy and diet on β-cell function in women with DM-1.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti
POVEZANOST RADA
Projekti:
108-1080401-0385 - Dijabetes i metabolički sindrom nakon prethodnog gestacijskog dijabetesa (Ivanišević, Marina, MZOS ) ( CroRIS)
108-1080401-0386 - Metaboličke i endokrine promjene u dijabetičnih trudnica (Đelmiš, Josip, MZOS ) ( CroRIS)
Ustanove:
Medicinski fakultet, Zagreb
Profili:
Marina Ivanišević
(autor)
Josip Đelmiš
(autor)
Erden Radončić
(autor)
Marina Horvatiček
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Scopus
Uključenost u ostale bibliografske baze podataka::
- EMBASE (Excerpta Medica)
- SCOPUS