Cadmium, iron and zinc interaction in mother rats and the offspring: does it change if exposure starts at the beginning of gestation or earlier?

Mikolić, Anja; Sulimanec Grgec, Antonija; Piasek, Martina

Pregled bibliografske jedinice broj: 787378

Cadmium, iron and zinc interaction in mother rats and the offspring: does it change if exposure starts at the beginning of gestation or earlier?

Mikolić, Anja; Sulimanec Grgec, Antonija; Piasek, Martina

Cadmium, iron and zinc interaction in mother rats and the offspring: does it change if exposure starts at the beginning of gestation or earlier? // Abstracts XI ISTERH Conference Recent Advances in Trace Element Research in Health and Disease ; u: Journal of Trace Elements in Medicine and Biology 32 (2015) (S) / Jurasović, Jasna ; Aschner, Michael (ur.).
Srebreno, Hrvatska: Elsevier, 2015. (poster, međunarodna recenzija, sažetak, znanstveni)

CROSBI ID: 787378 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Cadmium, iron and zinc interaction in mother rats and the offspring: does it change if exposure starts at the beginning of gestation or earlier?

Autori
Mikolić, Anja ; Sulimanec Grgec, Antonija ; Piasek, Martina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts XI ISTERH Conference Recent Advances in Trace Element Research in Health and Disease ; u: Journal of Trace Elements in Medicine and Biology 32 (2015) (S) / Jurasović, Jasna ; Aschner, Michael - : Elsevier, 2015

Skup
XI ISTERH Conference Recent Advances in Trace Element Research in Health and Disease

Mjesto i datum
Srebreno, Hrvatska, 18.11.2015. - 22.11.2015

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
cadmium; iron; zinc; prenatal exposure; foetus; placenta; newborn rat pup

Sažetak
The gastrointestinal absorption of Cd in rats is estimated at 0.3% to 3%, which increases during gestation. Cadmium accumulates in internal organs and placenta where it can interact with essential elements. We exposed rats (Wistar) to 50 mg Cd/L in drinking water during gestation days 1-20 or 4 weeks before and during gestation and evaluated Cd, Fe and Zn concentrations in mother rats and their offspring after exposure termination. The elements were analysed by electrothermal (Cd) or flame atomic absorption spectrometry (Fe and Zn). Cadmium increased in maternal liver and kidney, placentas, foetuses and newborn pups’ liver, kidney and brain. Iron decreased in maternal liver and kidney, foetuses and newborn pups’ liver, kidney and brain. Zinc increased in maternal liver and was reduced in maternal kidney and placenta only after the 20-day exposure during gestation. Irrespective of the beginning of maternal exposure, prenatal Cd exposure induces biochemical changes of Fe and Zn in maternal internal organs and additionally disrupts the transplacental transfer of Fe to the offspring.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Javno zdravstvo i zdravstvena zaštita, Prehrambena tehnologija

Napomena
Priopćenje je nagradio Znanstveni odbor kongresa.

POVEZANOST RADA

Projekti:
022-0222148-2135 - Izloženost metalima i njihovi učinci u graviditetu i postnatalnom razdoblju (Piasek, Martina, MZOS ) ( CroRIS)

Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb

Profili:

Martina Piasek (autor)