Pregled bibliografske jedinice broj: 786037
Effect of flavonoids and hyperthermal intraperitoneal chemotherapy (HIPEC) on tumour growth and micronucleus induction in mouse tumour model
Effect of flavonoids and hyperthermal intraperitoneal chemotherapy (HIPEC) on tumour growth and micronucleus induction in mouse tumour model // Zbornik sažetaka (12. Hrvatski biološki kongres s međunarodnim sudjelovanjem) / Klobučar, Göran ; Kopjar, Nevenka ; Gligora Udovič, Marija ; Lukša, Žaklin ; Jelić, Dušan (ur.).
Zagreb, 2015. str. 267.-268. (poster, domaća recenzija, sažetak, znanstveni)
CROSBI ID: 786037 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Effect of flavonoids and hyperthermal intraperitoneal chemotherapy (HIPEC) on tumour growth and micronucleus induction in mouse tumour model
Autori
Oršolić, Nada ; Kunštić, Martina ; Kukolj, Marina ; Sirovina, Damir
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Zbornik sažetaka (12. Hrvatski biološki kongres s međunarodnim sudjelovanjem)
/ Klobučar, Göran ; Kopjar, Nevenka ; Gligora Udovič, Marija ; Lukša, Žaklin ; Jelić, Dušan - Zagreb, 2015, 267.-268.
Skup
12. Hrvatski biološki kongres s međunarodnim sudjelovanjem
Mjesto i datum
Sveti Martin na Muri, Hrvatska, 18.09.2015. - 23.09.2015
Vrsta sudjelovanja
Poster
Vrsta recenzije
Domaća recenzija
Ključne riječi
hyperthermia ; chemotherapy ; flavonoids ; Ehrlich ascites tumour ; genotoxicity
Sažetak
Hyperthermia enhanced the clastogenicity of alkylating agents. We investigated whether quercetin (QU) or naringenin (NAR) can sensitize Ehrlich ascites tumour to cisplatin hyperthermal intraperitoneal chemotherapy (HIPEC) treatment and whether these flavonoids in combination with cisplatin can ameliorate cisplatin‐induced micronuclei in peripheral blood reticulocytes of mice. QU or NAR were administered to mice 7 and 3 days before implantation of EAT cells, while cisplatin (5 or 10 mg kg‐1) was injected intraperitoneally to normothermic or hyperthermic‐treated mice 3 days after implantation of EAT cells (2×106). Our study supports the claim that the QU or NAR in combined treatment with cisplatin has the potential to inhibit tumour growth in both normothermic and hyperthermic conditions and attenuate number of micronuclei in the peripheral blood reticulocytes of mice at normothermic condition but enhanced the clastogenicity of cisplatin agents in hyperthermal condition.
Izvorni jezik
Engleski
Znanstvena područja
Biologija, Temeljne medicinske znanosti, Farmacija
POVEZANOST RADA
Projekti:
119-0000000-1255 - Kemoprevencija rasta tumora polifenolnim sastavnicama (Oršolić, Nada, MZOS ) ( CroRIS)
Ustanove:
Prirodoslovno-matematički fakultet, Zagreb