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Pregled bibliografske jedinice broj: 786037

Effect of flavonoids and hyperthermal intraperitoneal chemotherapy (HIPEC) on tumour growth and micronucleus induction in mouse tumour model


Oršolić, Nada; Kunštić, Martina; Kukolj, Marina; Sirovina, Damir
Effect of flavonoids and hyperthermal intraperitoneal chemotherapy (HIPEC) on tumour growth and micronucleus induction in mouse tumour model // Zbornik sažetaka (12. Hrvatski biološki kongres s međunarodnim sudjelovanjem) / Klobučar, Göran ; Kopjar, Nevenka ; Gligora Udovič, Marija ; Lukša, Žaklin ; Jelić, Dušan (ur.).
Zagreb, 2015. str. 267.-268. (poster, domaća recenzija, sažetak, znanstveni)


CROSBI ID: 786037 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Effect of flavonoids and hyperthermal intraperitoneal chemotherapy (HIPEC) on tumour growth and micronucleus induction in mouse tumour model

Autori
Oršolić, Nada ; Kunštić, Martina ; Kukolj, Marina ; Sirovina, Damir

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Zbornik sažetaka (12. Hrvatski biološki kongres s međunarodnim sudjelovanjem) / Klobučar, Göran ; Kopjar, Nevenka ; Gligora Udovič, Marija ; Lukša, Žaklin ; Jelić, Dušan - Zagreb, 2015, 267.-268.

Skup
12. Hrvatski biološki kongres s međunarodnim sudjelovanjem

Mjesto i datum
Sveti Martin na Muri, Hrvatska, 18.09.2015. - 23.09.2015

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
hyperthermia ; chemotherapy ; flavonoids ; Ehrlich ascites tumour ; genotoxicity

Sažetak
Hyperthermia enhanced the clastogenicity of alkylating agents. We investigated whether quercetin (QU) or naringenin (NAR) can sensitize Ehrlich ascites tumour to cisplatin hyperthermal intraperitoneal chemotherapy (HIPEC) treatment and whether these flavonoids in combination with cisplatin can ameliorate cisplatin‐induced micronuclei in peripheral blood reticulocytes of mice. QU or NAR were administered to mice 7 and 3 days before implantation of EAT cells, while cisplatin (5 or 10 mg kg‐1) was injected intraperitoneally to normothermic or hyperthermic‐treated mice 3 days after implantation of EAT cells (2×106). Our study supports the claim that the QU or NAR in combined treatment with cisplatin has the potential to inhibit tumour growth in both normothermic and hyperthermic conditions and attenuate number of micronuclei in the peripheral blood reticulocytes of mice at normothermic condition but enhanced the clastogenicity of cisplatin agents in hyperthermal condition.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Farmacija



POVEZANOST RADA


Projekti:
119-0000000-1255 - Kemoprevencija rasta tumora polifenolnim sastavnicama (Oršolić, Nada, MZOS ) ( CroRIS)

Ustanove:
Prirodoslovno-matematički fakultet, Zagreb

Profili:

Avatar Url Marina Kukolj (autor)

Avatar Url Nada Oršolić (autor)

Avatar Url Damir Sirovina (autor)


Citiraj ovu publikaciju:

Oršolić, Nada; Kunštić, Martina; Kukolj, Marina; Sirovina, Damir
Effect of flavonoids and hyperthermal intraperitoneal chemotherapy (HIPEC) on tumour growth and micronucleus induction in mouse tumour model // Zbornik sažetaka (12. Hrvatski biološki kongres s međunarodnim sudjelovanjem) / Klobučar, Göran ; Kopjar, Nevenka ; Gligora Udovič, Marija ; Lukša, Žaklin ; Jelić, Dušan (ur.).
Zagreb, 2015. str. 267.-268. (poster, domaća recenzija, sažetak, znanstveni)
Oršolić, N., Kunštić, M., Kukolj, M. & Sirovina, D. (2015) Effect of flavonoids and hyperthermal intraperitoneal chemotherapy (HIPEC) on tumour growth and micronucleus induction in mouse tumour model. U: Klobučar, G., Kopjar, N., Gligora Udovič, M., Lukša, Ž. & Jelić, D. (ur.)Zbornik sažetaka (12. Hrvatski biološki kongres s međunarodnim sudjelovanjem).
@article{article, author = {Or\v{s}oli\'{c}, Nada and Kun\v{s}ti\'{c}, Martina and Kukolj, Marina and Sirovina, Damir}, year = {2015}, pages = {267.-268.}, keywords = {hyperthermia, chemotherapy, flavonoids, Ehrlich ascites tumour, genotoxicity}, title = {Effect of flavonoids and hyperthermal intraperitoneal chemotherapy (HIPEC) on tumour growth and micronucleus induction in mouse tumour model}, keyword = {hyperthermia, chemotherapy, flavonoids, Ehrlich ascites tumour, genotoxicity}, publisherplace = {Sveti Martin na Muri, Hrvatska} }
@article{article, author = {Or\v{s}oli\'{c}, Nada and Kun\v{s}ti\'{c}, Martina and Kukolj, Marina and Sirovina, Damir}, year = {2015}, pages = {267.-268.}, keywords = {hyperthermia, chemotherapy, flavonoids, Ehrlich ascites tumour, genotoxicity}, title = {Effect of flavonoids and hyperthermal intraperitoneal chemotherapy (HIPEC) on tumour growth and micronucleus induction in mouse tumour model}, keyword = {hyperthermia, chemotherapy, flavonoids, Ehrlich ascites tumour, genotoxicity}, publisherplace = {Sveti Martin na Muri, Hrvatska} }




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