Naslov
The effectiveness of quercetin on biomarkers for osteoporosis

Autori
Oršolić, Nada ; Đikić, Domagoj ; Nemrava, Johann ; Majcen, Patrik ; Kunštić, Martina ; Kukolj, Marina ; Rođak, Edi ; Goluža, Eleonora

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Zbornik sažetaka (12. Hrvatski biološki kongres s međunarodnim sudjelovanjem) / Klobučar, Göran ; Kopjar, Nevenka ; Gligora Udovič, Marija ; Lukša, Žaklin ; Jelić, Dušan - Zagreb, 2015, 265-266

Skup
12. Hrvatski biološki kongres s međunarodnim sudjelovanjem

Mjesto i datum
Sveti Martin na Muri, Hrvatska, 18.09.2015. - 23.09.2015

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
retinoic acid ; osteoporosis ; quercetin ; alendronate ; rat

Sažetak
Oxidative stress may lead to extensive bone loss and skeletal fragility, two characteristics of osteoporosis. We studied the bone‐protective effect of quercetin (QU) in the retinoic acid induced model of osteoporosis (RMO) and in healthy rats. Densitometry, osteocalcin (OC), Cterminal cross‐linked telopeptide (CTX), calcium (Ca) and phosphorus (P) content of bone femur, geometric measurement on the femur, histology, hematological and biochemical parameters as well as lipid peroxidation (MDA) and glutathione levels (GSH) of liver and kidney cells were applied to all groups. Retinoic acid administration (80 mg kg‐1) revealed significant increase in biochemical parameters, MDA level, OC and CTX values and a significant decrease in values of BMD, Ca and P in the femur and GSH levels in liver and kidney compared to control. Administration of QU intragastrically (100 mg kg‐1 bw) daily concomitant with retinoic acid resulted in significantly reduction of CTX values and MDA in comparison to RMO. QU also exerted positive effects on biochemical parameters, values of Ca and P, BMD values in distal part, femoral weight and length and the GSH level. Concomitant treatments of rats with retinoic acid and alendronate had toxic effect to animals and resulted in a significant decrease in body mass of 5.67% after two weeks. The protective role of the QU against the toxicity of retinoic acid‐induced osteoporosis in rats gives a hope that QU may have similar protective action in humans.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Farmacija

POVEZANOST RADA