Naslov
RAE-1γ ligand expression by MCMV vector promotes induction and maintenance of protective immune memory

Autori
Tršan, T., Busche, A., Abram, M., Wensveen, F., Lemmermann, N.A., Arapović, M., Babić, M., Tomić, A., Golemac, M., Brinkmann, M.M., Jäger, W., Oxenius, A., Polić, B., Krmpotić, A., Messerle, M., Jonjić, S.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
2nd Meeting of Middle European Societies for Immunology and Allergology / - , 2013

Skup
2nd Meeting of Middle European Societies for Immunology and Allergology

Mjesto i datum
Opatija, Hrvatska, 10.10.2013. - 13.10.2013

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
MCMV; CD8 T cell vaccine vector; NKG2D

Sažetak
NKG2D is a receptor with dual function in immune response to the viruses: it is the main activating NK cell receptor and co-stimulatory receptor on CD8 T cells. Therefore, it plays a role in innate immunity as well as in shaping of specific memory of adaptive arm of immune system. NKG2D signaling is triggered upon recognition of its ligands, the MHC I-like proteins induced by cellular stress. Murine cytomegalovirus expressing NKG2D ligand RAE-1γ (RAE-1γ MCMV) has been shown to be dramatically attenuated in vivo, but still managed to generate robust virus-specific CD8 T cell response (Slavuljica et al., 2010). When RAE- 1γMCMV was co-expressing foreign CD8 T cell epitope, it demonstrated capacity to serve as an excellent vaccine-vector due to highly protective CD8 T cells it induced. Moreover, RAE1γ-expressing MCMV retained its exceptional vector properties also in NKG2D deficient mice, revealing additional immune function of RAE1γ which is independent of NKG2D receptor.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA