Naslov
Metallothionein expression in mercury-exposed suckling rats and detoxification with selenium

Autori
Lazarus, Maja ; Orct, Tatjana ; Ljubojević, Marija ; Sekovanić, Ankica ; Jurasović, Jasna ; Sabolić, Ivan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts XI ISTERH Conference Recent Advances in Trace Element Research in Health and Disease ; u: Journal of Trace Elements in Medicine and Biology 32 (2015) (S) / Jurasović, Jasna ; Aschner, Michael - : Elsevier, 2015

Skup
XI ISTERH Conference Recent Advances in Trace Element Research in Health and Disease

Mjesto i datum
Srebreno, Hrvatska, 18.10.2015. - 22.10.2015

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
mercury exposure; metallothionein; selenium; suckling rat

Sažetak
Selenium (Se) supplementation has been shown to change the distribution and excretion of mercury (Hg) in suckling rats exposed to inorganic Hg. The effect of exogenous Se on the level and role of Hg-induced metallothionein (MT) expression in young animals has not yet been studied. Seven- day-old Wistar pups were orally pre-treated with Se (6 μmol Na2SeO3/kg b.w.) for 3 days, and then co-treated with Hg (6 μmol HgCl2/kg b.w.) for the following 4 days. This group (Se+Hg) was compared to groups treated with Hg or Se alone, or with a vehicle (Control). Immunoblotting analyses revealed strong MT expression in the kidney (P<0.001), but not in the liver of Hg-exposed rats. Hepatic MT was stimulated by Se treatment in Se and Se+Hg groups. Renal MT expression was lower in Se- supplemented rats exposed to Hg compared to the Hg-only group. Our study in suckling rats confirmed earlier results for adult animals, and indicated that the binding of Hg to selenoproteins may form an inert complex that cannot induce MT.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

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