Pregled bibliografske jedinice broj: 778603
Detection of correlated conformational fluctuations in intrinsically disordered proteins through paramagnetic relaxation interference
Detection of correlated conformational fluctuations in intrinsically disordered proteins through paramagnetic relaxation interference // Physical Chemistry Chemical Physics (PCCP), 18 (2016), 8; 5753-5758 doi:10.1039/C5CP04858C (međunarodna recenzija, članak, znanstveni)
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Naslov
Detection of correlated conformational fluctuations in intrinsically disordered proteins through paramagnetic relaxation interference
Autori
Kurzbach, Dennis ; Vanas, Agathe ; Flamm, Andrea G. ; Tarnoczi, Nicole ; Kontaxis, Georg ; Maltar-Strmečki, Nadica ; Widder, Katharina ; Hinderberger, Dariush ; Konrat, Robert
Izvornik
Physical Chemistry Chemical Physics (PCCP) (1463-9076) 18
(2016), 8;
5753-5758
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
disordered proteins ; relaxation ; NMR-based paramagnetic relaxation interference
Sažetak
Functionally relevant conformational states of intrinsically disordered proteins (IDPs) are typically concealed in a vast space of fast interconverting structures. Here we present a novel methodology, NMR-based paramagnetic relaxation interference (PRI), that allows for direct observation of concerted motions and cooperatively folded sub-states in IDPs. The proposed NMR technique is based on the exploitation of cross correlated electron- nuclear dipolar relaxation interferences in doubly spin- labeled proteins and probes the transient spatial encounter of electron-nucleus spin pairs.
Izvorni jezik
Engleski
Znanstvena područja
Fizika, Kemija
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
