Naslov
THE EFFECT OF AROMATIC AMINES IN THE THIYL- INDUCED REACTIONS OF POLYUNSATURATED FATTY ACIDS

Autori
Mihaljević, Branka ; Tartaro Bujak, Ivana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
13th Tihany Symposium on Radiation Chemistry / Wojnarovits, Laszlo ; Takacs, Erzsebet - , 2015, P55-P55

Skup
13th Tihany Symposium on Radiation Chemistry

Mjesto i datum
Balatonalmádi, Mađarska, 29.08.2015. - 03.09.2015

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
diphenylamine; lipid hydroperoxides; cis-trans isomers; thiyl radicals

Sažetak
Lipid peroxidation and geometrical isomerization are two main classes of reactions that are known in the context of reactivity of lipids toward free radicals. Both processes peroxidation and isomerization were detected in biomimetic model of linoleic acid in the presence of oxygen and thiols.1 Thiols are known repairing agents in case of lipid peroxidation, due to the H-donation towards peroxyl radicals. In doing so, thiols are precursors of thiyl radicals that can act as isomerizing agents for the fatty acid double bonds. The double-sward character of thiols towards biomolecules has been increasingly addressed in the last decade. Whether these processes can occur together or influence each other in the presence of some common antioxidant, such as aromatic amines and phenols, is presently unknown. We were interested in extending the investigation of the reactivity of thiols involving diphenylamine in aerobic conditions. We investigated the interaction of diphenylamine and 2-mercaptoethanol in the radical stress induced to linoleic acid under biomimetic conditions. As a measure of lipid peroxidation in model systems of linoleic acid we determined hydroperoxides of linoleic acid initiated by thiyl radicals which were generated by gamma radiolysis.2 The role of diphenylamine in protecting from linoleic acid geometrical isomerization was determined simultaneously by gas chromatography.3 The mechanistic scenario was defined contributing to a better understanding of complex interactions related to free radical stress and antioxidant activity, as well as of the mechanisms of aromatic amines reactivity. References: [1] B. Mihaljević, I. Tartaro, C. Ferreri, C. Chatgilialoglu, Org. Biomol. Chem. 9 (2011) 3541–3548. [2] B. Mihaljević, B. Katušin-Ražem, D. Ražem, Free Radical Biol. Med. 21 (1996) 53–63. [3] C. Ferreri, S. Kratzsch, O. Brede, B. Marciniak, C. Chatgilialoglu, Free Radical Biol. Med. 38 (2005) 1180–1187.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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