Naslov
Visfatin serum level and expression in subcutaneous and visceral adipose tissue in prepubertal boys

Autori
Novak, Sanja ; Divković, Dalibor ; Drenjančević, Ines ; Čosić, Anita ; Selthofer-Relatić, Kristina

Izvornik
Pediatric Obesity (2047-6310) 11 (2016), 5; 411-417

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
visfatin physiology ; subcutaneous adipose tissue ; visceral adipose tissue ; visfatin mRNA expression ; visfatin serum level ; childhood obesity

Sažetak
The biological role of visfatin in humans, especially in eutrophic and healthy children is not understood yet, except for its link to obesity related disorders in adolescents and adults. Objectives were to determine physiological values of serum visfatin concentrations, visfatin mRNA expression in subcutaneous (SAT) and visceral adipose tissue (VAT) and to correlate them with anthropometric/metabolic data in prepubertal healthy boys. Study included 59 healthy boys, age 1- 10 years, hospitalized for elective surgery, divided according to age into: group I (1-3 years), group II (3-7years), and group III (7- 10) years old. Anthropometric and biochemical measurements, visfatin serum and mRNA level in SAT and VAT were determined in all patients. RESULTS: Visfatin mRNA expression was higher in SAT compared to VAT in all three studied groups. Highest visfatin mRNA was found in SAT of group III compared to group II(P=0.030). VAT visfatin mRNA expression negatively correlates with body weight (P=0.039), waist circumference (P=0.027) and morning glucose level (P=0.007). Lack of changes in serum visfatin level despite the changes in visfatin mRNA expression of adipose tissue, suggest paracrine effect of visfatin rather than endocrine. Negative correlation of visfatin VAT mRNA expression with anthropometric parameters indicate important role of VAT visfatin in maturation and in glucose metabolism.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA