Naslov
Procalcitonine as a diagnostic biomarker in outhospital pneumonia in children

Autori
Švigir, Alen ; Mrkić-Kobal, Iva ; Navratil, Marta ; Banić, Ivana ; Rikić, Josipa ; Plavec, Davor ; Nogalo, Boro ; Turkalj, Mirjana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
2 Congress of the Croatian society of allergology and clinical immunology, CMA with international participation

Mjesto i datum
Zagreb, Hrvatska, 21.05.2015. - 23.05.2015

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
procalcitonine ; CXR ; children ; pneumonia

Sažetak
Procalcitonine is the precursor of the hormone calcitonine synthesized in parafolicular C- thyroid cells. Increased procalcitonine levels have been associated with localized and severe bacterial infections, non-infective systemic inflammation response, kidney failure and medular thyroid carcinoma. Studies have indicated that procalcitonine may be a more reliable biomarker of inflammation in the diagnostics of bacterial sepsis. to compare routine biomarkers of inflammation (ESR, leukocytes, CRP) with serum procalcitonine levels in association with chest X-ray (CXR) findings in children with outhospital pneumonia. Children aged 4-18 years were treated at Children`s Hospital Srebrnjak with clinical features corresponding to outhospital pneumonia. At first visit patients underwent physical examination, had blood samples taken for detection of inflammation biomarkers (erithrocyte sedimentation rate-ESR, C-reactive protein-CRP, white blood cell differential and procalcitonine), along with CXR. CXR findings were categorized into 4 groups according to size of infiltrate: 1.no infiltrate, 2minor unilateral pneumonia, 3.extensive unilateral pneumonia and 4.bilateral pneumonia. There was a statistically siginificant correlation of serum procalcitonine levels with CXR findings at diagnosis, as well as with serum CRP levels and ESR. There was no correlation between serum procalcitonine and total or segmented leukocyte count. When comparing serum procalcitonine levels with CXR findings, procalcitonine levels correlated well with size of CXR infiltrate as well as with other biomarkers of inflammation. Our results suggest that serum procalcitonine levels might be a valid diagnostic biomarker, but to validate its potential in the diagnostics and prognosis of outhospital penumonia in children, further reasearch is needed.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA