Naslov
A polymorphism in the TBX21 gene is associated with inadequate response to common asthma treatment in children

Autori
Banić, Ivana ; Rijavec, Matija ; Plavec, Davor ; Korošec, Peter ; Turkalj, Mirjana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
EAACI Congress 2015

Mjesto i datum
Barcelona, Španjolska, 06.06.2015. - 10.06.2015

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
asthma ; children ; TBX21 ; LABA

Sažetak
Inhaled corticosteroids (ICS) in combination with long-acting -adrenoreceptor agonists (LABA) are commonly used for asthma control and the level of response to such treatment is characterized by high intra-individual repeatability and high inter-individual variability with up to 50% of asthmatic patients having poor or even no response to treatment. Polymorphisms in TBX21, a gene important for the biological action of corticosteroids, could be associated with treatment response in asthmatics. To determine treatment outcomes in children with asthma in association with TBX21 (rs991008) genotype. We recruited 365 children with asthma and clinically assessed their health status and treatment outcome over 4 years at 3 time points: at the point of diagnosis, after 3 years and after 4 years. Genetic material was extracted from peripheral whole blood samples and these were then genotyped for rs9910408 polymorphism in the TBX21 gene. 96 children were treated with combination therapy (ICS+LABA) continuously for at least 4 years. When treatment success was assessed by changes in lung function parameters (Maximum expiratory flow at 50%, MEF50), the frequency of GG genotype was significantly higher in bad responders (p= 0, 0409) compared to the AA genotype. This genotype related response was even more evident when comparing patients with moderate and bad response to treatment with patients with good response: the frequency of GG genotype was also significantly higher in moderate and bad responders versus good responders (p= 0, 0152). The levels of response to treatment were defined as relative changes in MEF50 between clinical visits (assessments) at 3 time points. Our results showed that inadequate levels of response to treatment with ICS in combination with LABA in children with asthma, assessed as changes in lung function parameters (MEF50), are associated with a polymorphism in the TBX21 gene.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA